ArticleNature communications2023
Neural circuit selective for fast but not slow dopamine increases in drug reward.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03326245 (Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI
Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.Nature communications · 2025Trial
- Brain connectivity changes to fast versus slow dopamine increases.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Addictive Potential of Methylphenidate: A Systematic Review of Human and Preclinical Behavioral, Clinical and Neurobiological Evidence.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Blunted modulation of hierarchical brain organization in opioid use disorder.Research square · 2026Article
- An emerging role for synaptic ZnPharmacology & therapeutics · 2026Review
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- Lorcaserin modulation of semantic drug cue-elicited effective brain connectivity in persons with cocaine and opioid use disorders.Psychiatry research. Neuroimaging · 2025Article
- Olfactory Drug Delivery in Rodents: Deposition and Pharmacokinetics.ACS pharmacology & translational science · 2025Article
- Lifespan investigation of brain volumetric changes associated with substance use disorders.Research square · 2025Article
- Functional brain connectivity of the salience network in alcohol use and anxiety disorders.Journal of affective disorders · 2025Article
- Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Review
- Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural circuit selective for fast but not slow dopamine increases in drug reward.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved. With simultaneous PET-fMRI we linked dynamics of dopamine signaling, brain activity/connectivity, and self-reported 'high' in 20 adults receiving methylphenidate orally (results in slow delivery) and intravenously (results in fast delivery) (trial NCT03326245). We estimated speed of striatal dopamine increases to oral and IV methylphenidate and then tested where brain activity was associated with slow and fast dopamine dynamics (primary endpoint). We then tested whether these brain circuits were temporally associated with individual 'high' ratings to methylphenidate (secondary endpoint). A corticostriatal circuit comprising the dorsal anterior cingulate cortex and insula and their connections with dorsal caudate was activated by fast (but not slow) dopamine increases and paralleled 'high' ratings. These data provide evidence in humans for a link between dACC/insula activation and fast but not slow dopamine increases and document a critical role of the salience network in drug reward.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.