Evidence map›Paper›PMID 37938538›Full record

ArticlePurinergic signalling2024

Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A

Haiyan Li, Ji Aee Kim, Seong-Eun Jo, Huisu Lee, Kwan-Chang Kim, Shinkyu Choi, Suk Hyo Suh

Abstract read
In one paragraph

Article in Purinergic signalling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haiyan LiDepartment of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea.
Ji Aee KimDepartment of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea.
Seong-Eun JoDepartment of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea.
Huisu LeeDepartment of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea.
Kwan-Chang Kim *Department of Thoracic & Cardiovascular Surgery, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea. mdkkchang@ewha.ac.kr.
Shinkyu Choi *Department of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea. skchoi@ewha.ac.kr.
Suk Hyo Suh *Department of Physiology, College of Medicine, Ewha Womans University, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07084, Republic of Korea. shsuh@ewha.ac.kr.

Funding

Ewha Womans University Research Grant 1-2022-1108-001-1Intramural research promotion grants from Ewha Womans University, School of Medicine RP-2020National Research Foundation of Korea (NRF) grant NRF-2022R1A2C1007823National Research Foundation of Korea (NRF) grant NRF-2022R1A2C1092484
6 · The paper itself

Abstract

Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling. We investigated whether altered AR expression contributes to the development of fibrotic diseases and whether A

Indexed as

ModafinilReceptor, Adenosine A2AReceptor, Adenosine A2BUp-RegulationAnimalsAntifibrotic AgentsAnti-Inflammatory AgentsFibroblastsHumansIdiopathic Pulmonary FibrosisMaleMiceMice, Inbred C57BLAntifibrotic AgentsAnti-Inflammatory AgentsModafinilReceptor, Adenosine A2AReceptor, Adenosine A2BA2A and A2B adenosine receptorsEpac signallingFibrosisLung and liver

Identifiers

PMID37938538
PMCPMC11303359

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.