Evidence map›Paper›PMID 37938405›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

The incremental risk of fragility fractures in aging men.

A R Agarwal, O Tarawneh, J S Cohen, A Gu, K F Moseley, J N DeBritz, G J Golladay, S C Thakkar

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

A R AgarwalDepartment of Orthopaedic Surgery, George Washington University School of Medicine and, Health Sciences, Washington, DC, USA. amil_agarwal@gwmail.gwu.edu.ORCID http://orcid.org/0000-0002-0480-9515
O TarawnehDepartment of Orthopaedic Surgery, New York Medical College, Valhalla, NY, USA.
J S CohenDepartment of Orthopaedic Surgery, University of Pennsylvania, Philadelpha, PA, USA.
A GuDepartment of Orthopaedic Surgery, George Washington University School of Medicine and, Health Sciences, Washington, DC, USA.
K F MoseleyDepartment of Orthopaedic Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
J N DeBritzDepartment of Orthopaedic Surgery, George Washington University School of Medicine and, Health Sciences, Washington, DC, USA.
G J GolladayDepartment of Orthopaedic Surgery, Virginia Commonwealth University Health Center, Richmond, VA, USA.
S C ThakkarDepartment of Orthopaedic Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Johns Hopkins University · USGeorge Washington University · USNew York Medical College · USUniversity of Pennsylvania · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile the United States Preventative Services Task Force recommends osteoporosis screening for women 65 years and older, there is no definitive recommendation for routine osteoporosis screening in men. The purpose of this study was to determine the age at which the odds of fragility fractures (FFx) increase in men to help guide future policy discussions evaluating an optimal screening strategy in this population.

methodsMen older than 49 years were identified in the PearlDiver Patient Records Database. Patients were excluded if they had a prior fragility fracture, if they were at high risk for osteoporosis due to comorbidities, or if they carried a diagnosis of and/or were on treatment for osteoporosis. The prevalence of FFx was trended for each age group. A stratum-specific likelihood ratio (SSLR) analysis was conducted to identify data-driven strata that maximize the incremental FFx risk by age for men. Logistic regression analyses controlling for potential confounders were conducted to test these identified strata.

resultsThe incidence of FFx started to increase after the age of 64 years for men. Further, the identified data-driven age strata associated with a significant and incremental difference in fragility fractures were the following: 50-64, 65-69, 70-72, 73-75, 76-78, 79-80, and 81+. When compared to the youngest age stratum (50-64 years), multivariable regression showed the risk of fragility fracture incrementally increased starting in those aged 70-72 (RR, 1.31; 95% CI. 1.21-1.46; p < 0.001) with the highest risk in those aged 81+ (RR, 5.35; 95% CI, 5.10-5.62; p < 0.001).

conclusionIn men without a pre-existing history of osteoporosis, the risk of fragility fractures starts to increase after the age of 70. Further work building upon these data may help to identify a specific age at which routine bone health screening in males can help to minimize fractures and their associated morbidity and mortality.

Indexed as

Fractures, BoneOsteoporosisOsteoporotic FracturesAgingBone and BonesFemaleHumansIncidenceMaleRisk FactorsFragility fracturesMenStratum-specific likelihood ratioThresholds

Identifiers

PMID37938405
OpenAlexW4388496391

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.