Evidence map›Paper›PMID 37938347›Full record

ArticleHistochemistry and cell biology2024

Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life.

R Holota, V Dečmanová, A Alexovič Matiašová, J Košuth, L Slovinská, L Pačut, Z Tomori, Z Daxnerová, J Ševc

Open access · hybridAbstract read
In one paragraph

Article in Histochemistry and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

R HolotaInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.ORCID http://orcid.org/0009-0002-5942-4441
V DečmanováInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.ORCID http://orcid.org/0000-0003-0281-5126
A Alexovič MatiašováInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic. anna.alexovic.matiasova@upjs.sk.ORCID http://orcid.org/0000-0002-5500-4549
J KošuthInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.ORCID http://orcid.org/0000-0001-5584-8728
L SlovinskáAssociated Tissue Bank, Faculty of Medicine, P. J. Šafárik University in Košice and L. Pasteur University Hospital, Tr. SNP 1, 04011, Košice, Slovak Republic.ORCID http://orcid.org/0000-0002-9945-0655
L PačutInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.
Z TomoriInstitute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001, Košice, Slovak Republic.ORCID http://orcid.org/0000-0002-0685-0247
Z DaxnerováInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.ORCID http://orcid.org/0000-0002-5778-8033
J ŠevcInstitute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 04154, Košice, Slovak Republic.ORCID http://orcid.org/0000-0001-8050-4185
University of Pavol Jozef Šafárik · SKSlovak Academy of Sciences · SK

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-19-0279Vedecká grantová agentúra Ministerstva školstva, vedy, výskumu a športu Slovenskej republiky a Slovenskej akadémie vied VEGA 1/0760/20Vedecká grantová agentúra Ministerstva školstva, vedy, výskumu a športu Slovenskej republiky a Slovenskej akadémie vied VEGA 2/0101/22
6 · The paper itself

Abstract

Cell death is an essential process that occurs during the development of the central nervous system. Despite the availability of a wide range of commercially produced antibodies against various apoptotic markers, data regarding apoptosis in intact spinal cord during postnatal development and adulthood are mostly missing. We investigated apoptosis in rat spinal cord at different stages of ontogenesis (postnatal days 8, 29, and 90). For this purpose, we applied immunofluorescent detection of two widely used apoptotic markers, cleaved caspase-3 (cC3) and cleaved poly(ADP-ribose) polymerase (cPARP). Surprisingly, we found significant discrepancy between the number of cC3

Indexed as

ApoptosisNeurogliaAnimalsCaspase 3Poly(ADP-ribose) PolymerasesRatsSpinal CordCasp3 protein, ratCaspase 3Poly(ADP-ribose) PolymerasesApoptosisCleaved caspase-3Cleaved PARPDevelopmentRatSpinal cord

Identifiers

PMID37938347
PMCPMC10912154
OpenAlexW4388489619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.