ArticleISME communications2022
Gentamicin at sub-inhibitory concentrations selects for antibiotic resistance in the environment.
Article in ISME communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Programmable 3D Microfluidics Reveals Motility-Driven Antibiotic Resistance Evolution in Gradients.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Increased temperature selects for antibiotic resistance genes in a model aquatic ecosystem.npj antimicrobials and resistance · 2026Article
- Persistence of environmental and wastewater-associated antibiotic resistance in river water.Environmental monitoring and assessment · 2026Article
- Environmental Consequences of Anthropogenic Pollution: Non-antibiotic-Drug-Driven Antibiotic Resistance Selection in a Model Aquatic Ecosystem.Environment & health (Washington, D.C.) · 2026Article
- Combining Bile Salt with Gentamicin: A Promising Strategy Against Vibrio Parahaemolyticus and Escherichia Coli.Current microbiology · 2025Article
- Beyond the Resistome: Molecular Insights, Emerging Therapies, and Environmental Drivers of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Numerical Modeling of Gentamicin Transport in Agricultural Soils: Implications for Environmental Pollution.Antibiotics (Basel, Switzerland) · 2025Article
- The Role of the Environment (Water, Air, Soil) in the Emergence and Dissemination of Antimicrobial Resistance: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2025Review
- Impact of fluoroquinolone and heavy metal pollution on antibiotic resistance maintenance in aquatic ecosystems.Environmental microbiome · 2025Article
- Comprehensive Study of Antibiotics and Antibiotic Resistance Genes in Wastewater and Impacted Mediterranean Water Environments.Antibiotics (Basel, Switzerland) · 2025Article
- Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin.ISME communications · 2025Article
- Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes.Critical reviews in microbiology · 2024Review
- Sewage sludge fertilization affects microbial community structure and its resistome in agricultural soils.Scientific reports · 2024Article
- Bacterial dynamics of the plastisphere microbiome exposed to sub-lethal antibiotic pollution.Microbiome · 2024Article
- Article
- Development of anFrontiers in microbiology · 2024Article
- Oxytetracycline and heavy metals promote the migration of resistance genes in the intestinal microbiome by plasmid transfer.The ISME journal · 2023Article
- Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment.Scientific reports · 2023Article
- Sub-MIC antibiotics influence the microbiome, resistome and structure of riverine biofilm communities.Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics released into the environment at low (sub-inhibitory) concentrations could select for antibiotic resistance that might disseminate to the human microbiome. In this case, low-level anthropogenic sources of antibiotics would have a significant impact on human health risk. In order to provide data necessary for the evaluation of this risk, we implemented river water microcosms at both sub-inhibitory and inhibitory concentrations of gentamicin as determined previously based on bacterial growth in enriched media. Using metagenomic sequencing and qPCR/RT-qPCR, we assessed the effects of gentamicin on water bacterial communities and their resistome. A change in the composition of total and active communities, as well as a gentamicin resistance gene selection identified via mobile genetic elements, was observed during a two-day exposure. We demonstrated the effects of sub-inhibitory concentrations of gentamicin on bacterial communities and their associated resistome in microcosms (simulating in situ conditions). In addition, we established relationships between antibiotic dose and the magnitude of the community response in the environment. The scope of resistance selection under sub-inhibitory concentrations of antibiotics and the mechanisms underlying this process might provide the basis for understanding resistance dispersion and associated risks in relatively low impacted ecosystems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.