Evidence map›Paper›PMID 37937999›Full record

ArticleInfection and immunity2023

Essential role of

Matthew S Jung, M Blanca Piazuelo, Lee C Brackman, Mark S McClain, Holly M Scott Algood

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Fatty acids ofMicrobiology spectrum · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew S JungDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0009-0005-1700-4870
M Blanca PiazueloDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-0000-1324
Lee C BrackmanDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0009-0003-2142-9658
Mark S McClainDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-9857-4883
Holly M Scott AlgoodDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-3735-4649
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
N-terminal acylation and sorting of Helicobacter pylori lipoproteins and their role in host response to infectionR21AI163586 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALGOOD, HOLLY MARIE SCOTT, MCCLAIN, MARK S · 2022 to 2023
$491k
The role of Th17 cytokines in H.pylori infectionI01BX000915 · VA · VETERANS HEALTH ADMINISTRATION · PI HOLLY Marie Scott ALGOOD · 2011 to 2026
–
BLRD VA I01 BX000915NCI NIH HHS P30 CA068485NIAID NIH HHS R21 AI163586NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Bacterial lipoproteins are post-translationally modified with acyl chains, anchoring these proteins to bacterial membranes. In Gram-negative bacteria, three enzymes complete the modifications. Lgt (which adds two acyl chains) and LspA (which removes the signal peptide) are essential. Lnt (which adds a third acyl chain) is not essential in certain bacteria including

Indexed as

Helicobacter InfectionsHelicobacter pyloriAcyltransferasesAnimalsBacterial ProteinsHumansLipoproteinsMiceStomachToll-Like Receptor 2Acyltransferasesapolipoprotein N-acyltransferaseBacterial ProteinsLipoproteinsToll-Like Receptor 2gene expression profilingGram-negative bacteriaHelicobacter pylorilipoproteinsToll-like receptor 2

Identifiers

PMID37937999
PMCPMC10715074
OpenAlexW4388500657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.