ArticlePsychophysiology2024
Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease.
Article in Psychophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer's diseases with cognitive decline.GeroScience · 2026Article
- Individual cases of Parkinson's disease can be robustly classified using magnetoencephalography.NPJ Parkinson's disease · 2026Article
- Rapid Profiling of EEG Responses to Non-Invasive Brain Stimulation in Parkinson's Disease: A Biomarker-Driven Screening Framework.Biomedicines · 2026Article
- Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Article
- An L-shaped flexible neural implant for chronic ECoG signal acquisition in M2 region of control and Parkinsonian rat models.Scientific reports · 2025Article
- Dynamic excitation/inhibition balance preceding seizure onset and its link to functional and structural brain architecture.BMC medicine · 2025Article
- The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism.Journal of neurodevelopmental disorders · 2025Article
- Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Exploring background aperiodic electroencephalography (EEG) activity in the Bucharest Early Intervention Project.Developmental psychology · 2025Article
- Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years.bioRxiv : the preprint server for biology · 2024Article
- Test-retest reliability of spectral parameterization by 1/f characterization using SpecParam.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Changes in electrophysiological aperiodic activity during cognitive control in Parkinson's disease.Brain communications · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
Parkinson's disease (PD) has been associated with greater total power in canonical frequency bands (i.e., alpha, beta) of the resting electroencephalogram (EEG). However, PD has also been associated with a reduction in the proportion of total power across all frequency bands. This discrepancy may be explained by aperiodic activity (exponent and offset) present across all frequency bands. Here, we examined differences in the eyes-open (EO) and eyes-closed (EC) resting EEG of PD participants (N = 26) on and off medication, and age-matched healthy controls (CTL; N = 26). We extracted power from canonical frequency bands using traditional methods (total alpha and beta power) and extracted separate parameters for periodic (parameterized alpha and beta power) and aperiodic activity (exponent and offset). Cluster-based permutation tests over spatial and frequency dimensions indicated that total alpha and beta power, and aperiodic exponent and offset were greater in PD participants, independent of medication status. After removing the exponent and offset, greater alpha power in PD (vs. CTL) was only present in EO recordings and no reliable differences in beta power were observed. Differences between PD and CTL in the resting EEG are likely driven by aperiodic activity, suggestive of greater relative inhibitory neural activity and greater neuronal spiking. Our findings suggest that resting EEG activity in PD is characterized by medication-invariant differences in aperiodic activity which is independent of the increase in alpha power with EO. This highlights the importance of considering aperiodic activity contributions to the neural correlates of brain disorders.
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