Evidence map›Paper›PMID 37937733›Full record

ArticleThe Laryngoscope2024

Free Flap Outcomes for Head and Neck Surgery in Patients with COVID-19.

Aaron Domack, Morgan M Sandelski, Syed Ali, Keith E Blackwell, Marisa Buchakjian, Andrés M Bur, Steven B Cannady, Carlos X Castellanos, Yadranko Ducic, Tamer A Ghanem and 19 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Aaron DomackDepartment of Otolaryngology, Loyola University Medical Center, Maywood, Illinois, USA.
Morgan M SandelskiDepartment of Otolaryngology, Loyola University Medical Center, Maywood, Illinois, USA.
Syed AliDepartment of Otolaryngology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Keith E BlackwellDepartment of Otolaryngology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Marisa BuchakjianDepartment of Otolaryngology, University of Iowa Health Care, Iowa City, Iowa, USA.
Andrés M BurDepartment of Otolaryngology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0001-6879-6453
Steven B CannadyDepartment of Otolaryngology, University of Pennsylvania Medicine, Philadelphia, Pennsylvania, USA.
Carlos X CastellanosCaruso Department of Otolaryngology, University of Southern California, Los Angeles, California, USA.
Yadranko DucicDallas/Fort Worth, Head & Neck Cancer Center of Texas, Texas, USA.
Tamer A GhanemDepartment of Otolaryngology, Henry Ford Health, Detroit, Michigan, USA.
Andrew T HuangDepartment of Otolaryngology, Baylor College of Medicine, Houston, Texas, USA.
Ryan S JacksonDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, USA.
Niels KokotCaruso Department of Otolaryngology, University of Southern California, Los Angeles, California, USA.
Shawn LiDepartment of Otolaryngology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Patrik PipkornDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sidharth V PuramDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, USA.
Rod RezaeeDepartment of Otolaryngology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Karthik RajasekaranDepartment of Otolaryngology, University of Pennsylvania Medicine, Philadelphia, Pennsylvania, USA.
Yelizaveta ShnayderDepartment of Otolaryngology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Uttam K SinhaCaruso Department of Otolaryngology, University of Southern California, Los Angeles, California, USA.
Daniel SukatoDepartment of Otolaryngology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Neeraj SureshDepartment of Otolaryngology, University of Pennsylvania Medicine, Philadelphia, Pennsylvania, USA.
Akina TamakiDepartment of Otolaryngology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Carissa M ThomasDepartment of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-0765-5731
Eric J ThorpeDepartment of Otolaryngology, Loyola University Medical Center, Maywood, Illinois, USA.
Mark K WaxDepartment of Otolaryngology, Oregon Health & Science University, Portland, Oregon, USA.
Sara YangDepartment of Otolaryngology, Oregon Health & Science University, Portland, Oregon, USA.
Andrea ZieglerDepartment of Otolaryngology, Loyola University Medical Center, Maywood, Illinois, USA.
Amy L PittmanDepartment of Otolaryngology, Loyola University Medical Center, Maywood, Illinois, USA.

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

introductionCoronavirus disease 2019 (COVID-19) affects the vascular system, subjecting patients to a hypercoagulable state. This is of particular concern for the success of microvascular free flap reconstruction. This study aims to report head and neck free flap complications in patients with COVID-19 during the perioperative period. We believe these patients are more likely to experience flap complications given the hypercoagulable state.

methodsThis is a multi-institutional retrospective case series of patients infected with COVID-19 during the perioperative period for head and neck free flap reconstruction from March 2020 to January 2022.

resultsData was collected on 40 patients from 14 institutions. Twenty-one patients (52.5%) had a positive COVID-19 test within 10 days before surgery and 7 days after surgery. The remaining patients had a positive test earlier than 10 days before surgery. A positive test caused a delay in surgery for 16 patients (40.0%) with an average delay of 44.7 days (9-198 days). Two free flap complications (5.0%) occurred with no free flap deaths. Four patients (10.0%) had surgical complications and 10 patients had medical complications (25.0%). Five patients (12.5%) suffered from postoperative COVID-19 pneumonia. Three deaths were COVID-19-related and one from cancer recurrence during the study period.

conclusionDespite the heightened risk of coagulopathy in COVID-19 patients, head and neck free flap reconstructions in patients with COVID-19 are not at higher risk for free flap complications. However, these patients are at increased risk of medical complications. LEVEL OF EVIDENCE: 4 Laryngoscope, 134:4521-4526, 2024.

Indexed as

COVID-19Free Tissue FlapsHead and Neck NeoplasmsPlastic Surgery ProceduresPostoperative ComplicationsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2Treatment Outcomecoagulopathy in microvascular reconstructioncoronavirusCOVID‐19head and neck reconstructionmicrovascular free flapsurgical complications in COVID‐19

Identifiers

PMID37937733
PMCPMC12375219

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.