Evidence map›Paper›PMID 37937607›Full record

ArticleOncology reports2023

KLF4 suppresses the proliferation of perihilar cholangiocarcinoma by negatively regulating GDF15 and phosphorylating AKT.

Xiaoming Zhang, Weijia Wang, Chunlei Lu, Haifeng Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiaoming ZhangGeneral Surgery Center of Linyi People's Hospital, Linyi, Shandong 276000, P.R. China.
Weijia WangGeneral Surgery Center of Linyi People's Hospital, Linyi, Shandong 276000, P.R. China.
Chunlei LuGeneral Surgery Center of Linyi People's Hospital, Linyi, Shandong 276000, P.R. China.
Haifeng ZhangGeneral Surgery Center of Linyi People's Hospital, Linyi, Shandong 276000, P.R. China.
Linyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krüppel‑like factor 4 (KLF4) is a transcription factor which functions as a tumor suppressor or an oncogene in numerous types of solid tumors. However, its expression levels and function in perihilar cholangiocarcinoma (pCCA) have yet to be elucidated. In the present study, in order to investigate its roles in pCCA, reverse transcription‑quantitative PCR (RT‑qPCR), western blot analysis and immunohistochemistry were used to detect KLF4 expression in pCCA. The Chi‑squared test was used to analyze the associations between KLF4 and the clinicopathological features of patients with pCCA. Univariate and multivariate analyses were subsequently used to analyze the prognostic significance of KLF4. The tumor suppression of KLF4 was investigated for the purposes of illustrating its biological function both

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaKlatskin TumorCell ProliferationGrowth Differentiation Factor 15HumansKruppel-Like Factor 4Proto-Oncogene Proteins c-aktGDF15 protein, humanGrowth Differentiation Factor 15KLF4 protein, humanKruppel-Like Factor 4Proto-Oncogene Proteins c-aktgrowth/differentiation factor 15Krüppel‑like factor 4perihilar cholangiocarcinomaprognosisproliferation

Identifiers

PMID37937607
PMCPMC10652240
OpenAlexW4388415175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.