Evidence map›Paper›PMID 37937349›Full record

ArticleClinical transplantation2024

Association between neighborhood-based material deprivation and liver transplant waitlist registrants demographics and mortality.

Giuseppe Cullaro, Jin Ge, Brian P Lee, Jennifer C Lai, Sharad I Wadhwani

Open access · bronzeAbstract read
In one paragraph

Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Giuseppe CullaroDivision of Gastroenterology, University of California, San Francisco, California, USA.ORCID 0000-0002-2935-0245
Jin GeDivision of Gastroenterology, University of California, San Francisco, California, USA.ORCID 0000-0003-1574-1525
Brian P LeeDivision of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, California, USA.
Jennifer C LaiDivision of Gastroenterology, University of California, San Francisco, California, USA.ORCID 0000-0003-2092-6380
Sharad I WadhwaniDepartment of Pediatrics, University of California, San Francisco, California, USA.
University of California, San Francisco · USUniversity of Southern California · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Addressing social adversity to improve outcomes among children undergoing liver transplant: the role for a health advocate on the transplant teamK23DK132454 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WADHWANI, SHARAD · 2022 to 2025
$860k
Application of Novel Biomarkers of Renal Health in Cirrhosis Patients to Stratify Risk of Acute Kidney Injury Occurrence and ReversibilityK23DK131278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Giuseppe Cullaro · 2022 to 2026
$812k
Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized InterventionsK23AA029752 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, BRIAN PEI LIM · 2022 to 2025
$772k
NCATS NIH HHSNIAAA NIH HHS K23 AA029752NIDDK NIH HHS K23 DK131278NIDDK NIH HHS K23 DK132454NIDDK NIH HHS L30 DK133959NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

BACKGROUND &

aimsLiver transplantation for alcohol-related liver disease (ARLD) has increased. We examined temporal trends in ARLD listing practices by neighborhood deprivation and evaluated the impact of neighborhood deprivation on waitlist mortality.

methodsWe included all adults > 18 years listed 2008-2019 in the UNOS registry. Our primary exposure was the neighborhood socioeconomic deprivation index based on patients' listing zip codes. We determined temporal trends in an ARLD listing diagnosis. We modeled ARLD listing diagnosis using logistic regression and waitlist mortality using Cox proportional hazards models.

resultsThe waitlist contained an increasing proportion of patients listed with ARLD over the study period; however, this rate increased the least for patients from the most deprived tertile (p < .001). Patients from the most deprived tertile were the least likely to be listed with ARLD (OR: .97, 95CI: .95-.98). In our adjusted model, patients from the most deprived tertile had an increased hazard of waitlist mortality (OR: 1.10, 95CI: 1.06-1.14).

conclusionNeighborhood deprivation was associated with a decreased likelihood of being listed with ARLD, suggesting that transplant for ARLD is inequitably available. The increased mortality associated with neighborhood deprivation demands future work to uncover the underlying reasons for this disparity.

Indexed as

Liver DiseasesLiver TransplantationAdultDemographyHumansRetrospective StudiesWaiting Listscirrhosisliver transplantoutcomessocioeconomic deprivationwaitlist

Identifiers

PMID37937349
PMCPMC10842435
OpenAlexW4388494231

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.