Evidence map›Paper›PMID 37937142›Full record

ArticleFrontiers in medicine2023

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact.

Guido Filler, Sumit Dave, Victor Ritter, Sherry Ross, Davis Viprakasit, Joseph E Hatch, Jennifer Bjazevic, Jeremy Burton, Donna Gilleskie, Jason Gilliland and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Total flavonoids ofFrontiers in pharmacology · 2026
    Article
  2. Observational
  3. Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 2 countries.

Guido FillerDepartment of Paediatrics, Western University, London, ON, Canada.
Sumit DaveDepartment of Surgery, Western University, London, ON, Canada.
Victor RitterDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Sherry RossDepartment of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Davis ViprakasitDepartment of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Joseph E HatchDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jennifer BjazevicDepartment of Surgery, Western University, London, ON, Canada.
Jeremy BurtonDepartment of Surgery, Western University, London, ON, Canada.
Donna GilleskieDepartment of Economics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jason GillilandDepartment of Geography, Western University, London, ON, Canada.
Feng-Chang LinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Nina JainDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
J Andrew McClureDepartment of Surgery, Western University, London, ON, Canada.
Hassan RazviDepartment of Surgery, Western University, London, ON, Canada.
Vipin BhayanaDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Peter WangDepartment of Surgery, Western University, London, ON, Canada.
Sherry CoulsonDepartment of Paediatrics, Western University, London, ON, Canada.
Nabil SultanDepartment of Medicine, Western University, London, ON, Canada.
John DenstedtDepartment of Surgery, Western University, London, ON, Canada.
Loretta FearringtonNorth Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Maria E Diaz-Gonzalez de FerrisDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Western University · CAUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Urinary stone disease (USD) historically has affected older men, but studies suggest recent increases in women, leading to a near identical sex incidence ratio. USD incidence has doubled every 10 years, with disproportionate increases amongst children, adolescent, and young adult (AYA) women. USD stone composition in women is frequently apatite (calcium phosphate), which forms in a higher urine pH, low urinary citrate, and an abundance of urinary uric acid, while men produce more calcium oxalate stones. The reasons for this epidemiological trend are unknown. Methods: This perspective presents the extent of USD with data from a Canadian Province and a North American institution, explanations for these findings and offers potential solutions to decrease this trend. We describe the economic impact of USD. Findings: There was a significant increase of 46% in overall surgical interventions for USD in Ontario. The incidence rose from 47.0/100,000 in 2002 to 68.7/100,000 population in 2016. In a single United States institution, the overall USD annual unique patient count rose from 10,612 to 17,706 from 2015 to 2019, and the proportion of women with USD was much higher than expected. In the 10-17-year-old patients, 50.1% were girls; with 57.5% in the 18-34 age group and 53.6% in the 35-44 age group. The roles of obesity, diet, hormones, environmental factors, infections, and antibiotics, as well as the economic impact, are discussed. Interpretation: We confirm the significant increase in USD among women. We offer potential explanations for this sex disparity, including microbiological and pathophysiological aspects. We also outline innovative solutions - that may require steps beyond typical preventive and treatment recommendations.

Indexed as

dietenvironmental factorshormonesobesitypopulation-based epidemiologysex differencesurinary phthalatesurinary stone disease

Identifiers

PMID37937142
PMCPMC10626457
OpenAlexW4387878230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.