Evidence map›Paper›PMID 37936714›Full record

ArticleFrontiers in immunology2023

CD14

Kristina Ludwig, Evgeny Chichelnitskiy, Jenny F Kühne, Bettina Wiegmann, Jasper Iske, Nadine Ledwoch, Fabio Ius, Kerstin Beushausen, Jana Keil, Susanne Iordanidis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Kristina LudwigInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Evgeny ChichelnitskiyInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Jenny F KühneInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Bettina WiegmannDepartment for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Jasper IskeInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Nadine LedwochInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Fabio IusDepartment for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Kerstin BeushausenInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Jana KeilInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Susanne IordanidisInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Sebastian V RojasHeart and Diabetes Center Nordrhein-Westfalen, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
Jawad SalmanDepartment for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Ann-Kathrin KnoefelDepartment for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Axel HaverichDepartment for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Gregor WarneckeDepartment of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Christine S FalkInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEGerman Center for Lung Research · DEDeutsches Herzzentrum der Charité · DEHeart and Diabetes Center North Rhine-Westphalia · DEHumboldt-Universität zu Berlin · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Following heart transplantation, a cascade of immunological responses is initiated influencing the clinical outcome and long-term survival of the transplanted patients. The anti-inflammatory cytokine interleukin-10 (IL-10) was shown to be elevated in the blood of heart transplant recipients directly after transplantation but the releasing cell populations and the composition of lymphocyte subsets following transplantation have not been thoroughly studied. Methods: We identified immune cells by immunophenotyping and analyzed intracellular IL-10 production in peripheral blood mononuclear cells (PBMC) of heart transplanted patients (n= 17) before, directly after and 24h post heart transplantation. The cells were stimulated with lipopolysaccharide or PMA/Ionomycin to enhance cytokine production within leukocytes Results and discussion: We demonstrate that intermediate monocytes (CD14

Indexed as

Heart TransplantationMonocytesCytokinesHumansInterleukin-10Leukocytes, MononuclearLipopolysaccharide ReceptorsReceptors, IgGCytokinesInterleukin-10Lipopolysaccharide ReceptorsReceptors, IgGheart transplantationinterleukin-10ischemia-reperfusion injurymonocytesorgan transplantation

Identifiers

PMID37936714
PMCPMC10627027
OpenAlexW4387869003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.