Evidence map›Paper›PMID 37936689›Full record

ReviewFrontiers in immunology2023

Material matters: exploring the interplay between natural biomaterials and host immune system.

Alok Shiomurti Tripathi, Magdi E A Zaki, Sami A Al-Hussain, Bidhyut Kumar Dubey, Prabhjot Singh, Laiba Rind, Rajnish Kumar Yadav

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alok Shiomurti TripathiDepartment of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad lbn Saud Islamic University, Riyadh, Saudi Arabia.
Sami A Al-HussainDepartment of Chemistry, Faculty of Science, Imam Mohammad lbn Saud Islamic University, Riyadh, Saudi Arabia.
Bidhyut Kumar DubeyDepartment of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, India.
Prabhjot SinghDepartment of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India.
Laiba RindDepartment of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India.
Rajnish Kumar YadavDepartment of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India.
Era's Lucknow Medical College and Hospital · INImam Mohammad ibn Saud Islamic University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials are widely used for various medical purposes, for instance, implants, tissue engineering, medical devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, and cell-specific sources. However, when these biomaterials are introduced into the body, they trigger an immune response which may lead to rejection and failure of the implanted device or tissue. The immune system recognizes natural biomaterials as foreign substances and triggers the activation of several immune cells, for instance, macrophages, dendritic cells, and T cells. These cells release pro-inflammatory cytokines and chemokines, which recruit other immune cells to the implantation site. The activation of the immune system can lead to an inflammatory response, which can be beneficial or detrimental, depending on the type of natural biomaterial and the extent of the immune response. These biomaterials can also influence the immune response by modulating the behavior of immune cells. For example, biomaterials with specific surface properties, such as charge and hydrophobicity, can affect the activation and differentiation of immune cells. Additionally, biomaterials can be engineered to release immunomodulatory factors, such as anti-inflammatory cytokines, to promote a tolerogenic immune response. In conclusion, the interaction between biomaterials and the body's immune system is an intricate procedure with potential consequences for the effectiveness of therapeutics and medical devices. A better understanding of this interplay can help to design biomaterials that promote favorable immune responses and minimize adverse reactions.

Indexed as

Biocompatible MaterialsMacrophagesCytokinesImmunityTissue EngineeringBiocompatible MaterialsCytokinesimmune responseimmuno-engineeringnatural biomaterialsregenerative medicinetissue engineering

Identifiers

PMID37936689
PMCPMC10627157
OpenAlexW4387869173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.