Evidence map›Paper›PMID 37936628›Full record

ArticleCardiology research2023

Temporal Trends in the United States Patent Landscape: Innovation in Cardiology Across Industry and Academia.

Raoul R Wadhwa, Brenna M McElderry, James Yu, Samir R Kapadia, A Marc Gillinov, Lars G Svensson, Milind Y Desai

Open access · diamondAbstract read
In one paragraph

Article in Cardiology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Raoul R WadhwaCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Brenna M McElderryDepartment of Internal Medicine, Cleveland Clinic, OH 44195, USA.
James YuSchool of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Samir R KapadiaCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
A Marc GillinovCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Lars G SvenssonCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Milind Y DesaiCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Cleveland Clinic · USCase Western Reserve University · USCleveland Clinic Lerner College of Medicine · US

Funding

Training Clinician Scientists as Outstanding Clinicians and Imaging ScientistsT32EB028093 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI ROBERT F MATTREY, Takeshi Yokoo · 2019 to 2026
$1.5M
NIBIB NIH HHS T32 EB028093
6 · The paper itself

Abstract

Background: Novel approaches to diagnostics and therapeutics in medical care reflect the scientific community's evolving understanding of disease states and their clinical implications. Marketable and valuable innovations are generally patented for protection of intellectual property. Here, we explore the landscape of cardiology-related patents in the United States. Methods: All United States patents granted between 2005 and 2020 were included in this study. Keywords filtering was used to identify patents related to cardiovascular medicine. Statistical inference was conducted with the Mann-Kendall trend and analysis of variance tests. The results in this report are entirely reproducible with Python and R scripts available in a publicly accessible repository. Results: Of the 4,453,733 patents issued by the USPTO between 2005 and 2020, 31,048 (0.7%) were identified as cardiology-related patents. We identified the top 10 institutions within the for-profit and not-for-profit categories that were assigned the most cardiology-related patents in this time period. Distributions of number of patents per inventor were heavily right-skewed, with a small number of inventors responsible for a large number of patents each. Patents in the cardiac imaging subgroup took the longest to gain approval after submission (median delay: 3.6 years). Conclusions: By studying the patent universe, we are able to identify underexplored areas within cardiovascular medicine. Obstacles such as long delays between patent application and approval can hamper innovation within a field. As a next step, we aim to use these results to predict the next area within cardiovascular medicine to undergo explosive research and innovation.

Indexed as

CardiologyInnovationPatentTemporal trends

Identifiers

PMID37936628
PMCPMC10627376
OpenAlexW4387941192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.