Evidence map›Paper›PMID 37936486›Full record

ArticleJournal of the American Geriatrics Society2024

Caregiving and all-cause mortality in postmenopausal women: Findings from the Women's Health Initiative.

Prachi P Chavan, Julie C Weitlauf, Michael J LaMonte, Sue Ann Sisto, Machiko Tomita, Dolores Gallagher-Thompson, Aladdin H Shadyab, Julie T Bidwell, JoAnn E Manson, Candyce H Kroenke and 6 more

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Prachi P ChavanDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
Julie C WeitlaufVeterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Michael J LaMonteDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.ORCID 0000-0002-6669-5242
Sue Ann SistoDepartment of Rehabilitation Sciences, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
Machiko TomitaDepartment of Rehabilitation Sciences, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
Dolores Gallagher-ThompsonDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human, University of California San Diego, Longevity Science, La Jolla, California, USA.
Julie T BidwellBetty Irene Moore School of Nursing, Family Caregiving Institute, University of California Davis, Sacramento, California, USA.
JoAnn E MansonDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
Candyce H KroenkeKaiser Permanente North Carolina, Division of Research, Oakland, California, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Calvin H HirschDivision of General Medicine, University of California Davis Medical Center, Sacramento, California, USA.
Charles P MoutonOffice of Provost, University of Texas Medical Branch, Galveston, Texas, USA.
Michael B CannellDepartment of Epidemiology, Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center, Dallas, Texas, USA.
Kathleen M HoveyDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
Social networks and disparities in health behaviors and breast cancer outcomes in immigrant womenR01CA230440 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KROENKE, CANDYCE H · 2019 to 2024
$3.2M
An Electronic Health Record-Based Tool to Identify Newly Diagnosed Breast Cancer Patients at Risk of Low Social SupportR01CA253028 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KROENKE, CANDYCE H · 2020 to 2025
$2.6M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032122 · WH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TREVISAN, MAURIZIO · 1993 to 2000
$927k
NCI NIH HHS R01 CA230440NCI NIH HHS R01 CA253028NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NIH HHS 75N92021NIH HHS 75N92021D00001NIH HHS 75N92021D00002NIH HHS 75N92021D00003NIH HHS 75N92021D00004NIH HHS 75N92021D00005WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005WHI NIH HHS N01 WH032122
6 · The paper itself

Abstract

backgroundCaregiving is commonly undertaken by older women. Research is mixed, however, about the impact of prolonged caregiving on their health, well-being, and mortality risk. Using a prospective study design, we examined the association of caregiving with mortality in a cohort of older women.

methodsParticipants were 158,987 postmenopausal women aged 50-79 years at enrollment into the Women's Health Initiative (WHI) who provided information on current caregiving status and caregiving frequency at baseline (1993-1998) and follow-up (2004-2005). Mortality was ascertained from baseline through March of 2019. Cox regression with caregiving status defined as a time-varying exposure was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for mortality, adjusting for sociodemographic factors, smoking, and history of diabetes, hypertension, cardiovascular disease (CVD), and cancer. Stratified analyses explored whether age, race-ethnicity, depressive symptoms, frequency of caregiving, optimism, and living status modified the association between caregiver status and mortality.

resultsAt baseline, 40.7% of women (mean age 63.3 years) self-identified as caregivers. During a mean 17.5-year follow-up, all-cause mortality (50,526 deaths) was 9% lower (multivariable-adjusted HR = 0.91, 95% CI: 0.89-0.93) in caregivers compared to non-caregivers. The inverse association between caregiving and all-cause mortality did not differ according to caregiving frequency or when stratified by age, race-ethnicity, depressive symptoms, optimism, or living status (interaction p > 0.05, all). Caregiving was inversely associated with CVD and cancer mortality.

conclusionAmong postmenopausal women residing across the United States, caregiving was associated with lower mortality. Studies detailing the type and amount of caregiving are needed to further determine its impact on older women.

Indexed as

Cardiovascular DiseasesNeoplasmsAgedFemaleFollow-Up StudiesHumansPostmenopauseProportional Hazards ModelsProspective StudiesRisk FactorsUnited StatesWomen's Healthcaregivingepidemiologymortalitypostmenopausalwomen's health

Identifiers

PMID37936486
PMCPMC10841917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.