ArticleThe Plant cell2024
H2O2 negatively regulates aluminum resistance via oxidation and degradation of the transcription factor STOP1.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Analysis of the sorghumGM crops & food · 2026Article
- A redox-regulated RCC1-like protein controls catalase activity in Arabidopsis.Nature communications · 2026Article
- Acidic and Alkaline pH Stresses Impair Tomato Seed Germination and Seedling Growth via Disruption of Reactive Oxygen Species and Auxin Homeostasis.Plants (Basel, Switzerland) · 2026Article
- A novel SlSTOP1-SlHAK5-cytosolic pH feedback loop drives dual adaptation to proton and aluminum toxicity in tomato.Horticulture research · 2025Article
- A shield of phosphorylation: MPK3/6 protect STOP1 from PUB24-mediated degradation under hypoxia.The Plant cell · 2025Article
- WRKY61 Negatively Regulates Aluminum Resistance by Inhibiting the Expression ofPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification and Expression Analysis of Mitochondrial Dicarboxylate Carriers (DICs) in Medicago Under Aluminum Stress.Plants (Basel, Switzerland) · 2025Article
- Genome-Wide Thioredoxin System inBiology · 2025Article
- Review
- CaNature communications · 2025Article
- CPK28-mediated CaNature communications · 2025Article
- Article
- Aluminum resistance in plants: A critical review focusing on STOP1.Plant communications · 2025Review
- SlSTOP1-regulatedHorticulture research · 2024Article
- Overexpression of cassava melatonin receptor PMTR1 plays dual roles in development under light and dark conditions in Arabidopsis.Plant cell reports · 2024Article
- Sensing the toxic aluminum cations in acidic soils.Cell research · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Aluminum (Al) stress triggers the accumulation of hydrogen peroxide (H2O2) in roots. However, whether H2O2 plays a regulatory role in aluminum resistance remains unclear. In this study, we show that H2O2 plays a crucial role in regulation of Al resistance, which is modulated by the mitochondrion-localized pentatricopeptide repeat protein REGULATION OF ALMT1 EXPRESSION 6 (RAE6). Mutation in RAE6 impairs the activity of complex I of the mitochondrial electron transport chain, resulting in the accumulation of H2O2 and increased sensitivity to Al. Our results suggest that higher H2O2 concentrations promote the oxidation of SENSITIVE TO PROTON RHIZOTOXICITY 1 (STOP1), an essential transcription factor that promotes Al resistance, thereby promoting its degradation by enhancing the interaction between STOP1 and the F-box protein RAE1. Conversely, decreasing H2O2 levels or blocking the oxidation of STOP1 leads to greater STOP1 stability and increased Al resistance. Moreover, we show that the thioredoxin TRX1 interacts with STOP1 to catalyze its chemical reduction. Thus, our results highlight the importance of H2O2 in Al resistance and regulation of STOP1 stability in Arabidopsis (Arabidopsis thaliana).
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