ArticleBMC psychiatry2023
Identifying major depressive disorder with associated sleep disturbances through fMRI regional homogeneity at rest.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association of Left Angular Gyrus-Right Middle Frontal Gyrus Functional Connectivity With Insomnia Severity in Major Depressive Disorder: Evidence From the DIRECT Consortium.CNS neuroscience & therapeutics · 2026Article
- Effects of sleep quality on the default mode network and on anxiety-depression symptoms in premenstrual syndrome.BMC psychiatry · 2025Article
- Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Unraveling Hierarchical Brain Dysfunction in Major Depressive Disorder: A Multimodal Imaging and Transcriptomic Approach.Human brain mapping · 2025Article
- Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder.World journal of psychiatry · 2025Article
- Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder.General psychiatry · 2024Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundAnomalies in regional homogeneity (ReHo) have been documented in patients with major depressive disorder (MDD) and sleep disturbances (SDs). This investigation aimed to scrutinize changes in ReHo in MDD patients with comorbid SD, and to devise potential diagnostic biomarkers for detecting sleep-related conditions in patients with MDD.
methodsPatients with MDD and healthy controls underwent resting-state functional magnetic resonance imaging scans. SD severity was quantified using the 17-item Hamilton Rating Scale for Depression. Subsequent to the acquisition of imaging data, ReHo analysis was performed, and a support vector machine (SVM) method was employed to assess the utility of ReHo in discriminating MDD patients with SD.
resultsCompared with MDD patients without SD, MDD patients with SD exhibited increased ReHo values in the right posterior cingulate cortex (PCC)/precuneus, right median cingulate cortex, left postcentral gyrus (postCG), and right inferior temporal gyrus (ITG). Furthermore, the ReHo values in the right PCC/precuneus and ITG displayed a positive correlation with clinical symptoms across all patients. SVM classification results showed that a combination of abnormal ReHo in the left postCG and right ITG achieved an overall accuracy of 84.21%, a sensitivity of 81.82%, and a specificity of 87.50% in identifying MDD patients with SD from those without SD.
conclusionWe identified disrupted ReHo patterns in MDD patients with SD, and presented a prospective neuroimaging-based diagnostic biomarker for these patients.
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