Evidence map›Paper›PMID 37936082›Full record

ArticleBMC psychiatry2023

Comparison of olfactory function, cognitive function and serum tumor necrosis factor-α between bipolar and schizophrenic patients in the remission stage.

Langjun Su, Xianlin Liu, Yingying Li, Huiqian Yuan, Qiping Li, Chunyang Li

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. [Depressive disorders and olfactory dysfunction].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Langjun SuDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China.
Xianlin LiuDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China.
Yingying LiDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China.
Huiqian YuanDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China.
Qiping LiDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China.
Chunyang LiDepartment of Psychiatry, Shunde WuZhongpei Memorial Hospital, No. 7 Baolin Road, Daliang Town, Shunde District, Foshan City, 528300, Guangdong, P.R. China. lichunyangwzp@163.com.
The First People's Hospital of Shunde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOlfactory function, serum tumor necrosis factor-α (TNF-α) and cognitive function were compared between bipolar disorder (BD) and schizophrenia (SP) patients in the remission stage combined with correlation analysis, with the aim of identifying new indicators for the auxiliary diagnosis of these psychiatric illnesses.

methodsA total of 46 euthymic BD patients, 42 clinically stable SP patients and 42 healthy controls (HC) were included in this study. Olfactory sensitivity (OS) and olfactory identification (OI) were assessed using Sniffin' Sticks test, and serum TNF-α levels were measured by ELISA. Clinical symptoms were evaluated with the Hamilton Rating Scale for Depression, Young Mania Rating Scale, Hamilton anxiety scale, and the Positive and Negative Syndrome Scale (PANSS). Social function was evaluated with the Global Assessment Function (GAF) scale. Cognitive function was evaluated using the Trail Making Test-A (TMT-A) and Digit Cancellation Test (DCT).

resultsOI and cognitive function scores and serum TNF-α levels were significantly lower in the BD and SP patients compared with the HC participants. There was no significant difference between the BD and SP groups, and there were no significant differences in OS among the three groups. OI score was positively correlated with years of education in both the BD and SP groups. OI score in the SP group was negatively correlated with age and PANSS score, and positively correlated with GAF score. In the BD group, OS was positively correlated with DCT II and DCT III. In the SP group, OS and OI scores were positively correlated with DCT III, and negatively correlated with TMT-A time. Furthermore, there was a positive correlation between TNF-α and DCT II in the BD group. There was no significant linear correlation between olfactory function and TNF-α in the BD or SP group.

conclusionOI may be a trait marker for BD and SP. Some cognitive functions may be correlated not only with TNF-α in BD patients in remission, but also with olfactory function in BD and SP patients in remission.

Indexed as

Bipolar DisorderSchizophreniaCognitionCyclothymic DisorderHumansTumor Necrosis Factor-alphaTNF protein, humanTumor Necrosis Factor-alphaBipolar disorderCognitive functionOlfactory identificationOlfactory sensitivityRemission stageSchizophreniaTumor necrosis factor-α

Identifiers

PMID37936082
PMCPMC10631022
OpenAlexW4388446765

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.