ArticleJournal of neurology2024
Persistent cognitive slowing in post-COVID patients: longitudinal study over 6 months.
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- [Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies].Revista de neurologia · 2025Pooled it
- Preliminary effects of mobile computerized cognitive training in adults with mild cognitive impairment: interim analysis of a randomized controlled trial.BMC psychology · 2025Trial
- Towards a Neurocognitive Profile of Post-Acute COVID-19: A Longitudinal Study Integrating Subjective Complaints and Computerized Cognitive Testing.Brain sciences · 2026Article
- [The importance of psychiatry in the care and research of Post-COVID].Der Nervenarzt · 2026Review
- Neurocognitive and Neuropsychiatric Trajectories in a Post-COVID Cohort: A Descriptive Longitudinal Study.Neurology international · 2026Article
- Article
- Magnetoencephalography Reveals Neuroprotection of COVID-19 Vaccination in Nonhuman Primates.Vaccines · 2026Article
- Longitudinal stability of cognitive impairments in post-COVID-19 syndrome assessed with the tablet-based Oxford Cognitive Screen-Plus.Scientific reports · 2026Article
- Cognitive impairment, depression, and fatigue in post-COVID and post-vaccination syndrome: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Altered core depressive symptom balance in post-COVID fatigue: reduced depressed mood in an exploratory matched historical-control study.Frontiers in psychiatry · 2026Article
- Cognitive Trajectories After Hospitalization for COVID-19: A 36-Month Longitudinal Study.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Cognitive functioning in young adults after mild COVID-19: A case-control study from Iran.IBRO neuroscience reports · 2025Article
- Evidence for a severe cognitive subgroup in a comprehensive neuropsychological Post-COVID-19 syndrome classification.Scientific reports · 2025Article
- Long-lasting effects on cognition and mental health in patients with post COVID-19 condition following a mild SARS-CoV-2 infection: A longitudinal case-control study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Validity of the test for attentional performance in neurological post-COVID condition.Scientific reports · 2025Article
- Altered putamen connectivity in patients with neurological post-COVID condition.Brain communications · 2025Article
- Article
- Course of neuropsychological health in post-COVID patients differs 6 and 12 months after inpatient rehabilitation.Frontiers in psychiatry · 2025Article
- A tablet-based intervention study to alleviate cognitive and psychological symptoms in patients with post-Covid-19 condition.Frontiers in psychology · 2025Article
- Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFatigue is a frequent and one of the most debilitating symptoms in post-COVID syndrome (PCS). Recently, we proposed that fatigue is caused by hypoactivity of the brain's arousal network and reflected by a reduction of cognitive processing speed. However, it is unclear whether cognitive slowing is revealed by standard neuropsychological tests, represents a selective deficit, and how it develops over time.
objectivesThis prospective study assesses whether PCS patients show deficits particularly in tests relying on processing speed and provides the first longitudinal assessment focusing on processing speed in PCS patients.
methodsEighty-eight PCS patients with cognitive complaints and 50 matched healthy controls underwent neuropsychological assessment. Seventy-seven patients were subsequently assessed at 6-month follow-up. The Test for Attentional Performance measured tonic alertness as primary study outcome and additional attentional functions. The Neuropsychological Assessment Battery evaluated all key cognitive domains.
resultsPatients showed cognitive slowing indicated by longer reaction times compared to control participants (r = 0.51, p < 0.001) in a simple-response tonic alertness task and in all more complex tasks requiring speeded performance. Reduced alertness correlated with higher fatigue (r = - 0.408, p < 0.001). Alertness dysfunction remained unchanged at 6-month follow-up (p = 0.240) and the same was true for most attention tasks and cognitive domains.
conclusionHypoarousal is a core deficit in PCS which becomes evident as a selective decrease of processing speed observed in standard neuropsychological tests. This core deficit persists without any signs of amelioration over a 6-month period of time.
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