Evidence map›Paper›PMID 37936001›Full record

ArticleInternational ophthalmology2023

Association of NLRPs with pathogenesis of dry age-related macular degeneration.

Yiyun Zeng, Wentao Dong, Wanqiu Zhang, Bolin Deng

Abstract read
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In one paragraph

Article in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yiyun Zeng *Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32# W. Sec 2, 1St Ring Rd., Chengdu, 611731, Sichuan, China.
Wentao Dong *Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32# W. Sec 2, 1St Ring Rd., Chengdu, 611731, Sichuan, China.
Wanqiu ZhangDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32# W. Sec 2, 1St Ring Rd., Chengdu, 611731, Sichuan, China. 14064948@qq.com.
Bolin DengDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32# W. Sec 2, 1St Ring Rd., Chengdu, 611731, Sichuan, China. dengbolin@uestc.edu.cn.
University of Electronic Science and Technology of China · CN

Funding

the National University Basic funding ZYGX2018J098the Scientific Research Project of Sichuan Provincial People's Hospital 2021kflx007the Youth Scientific Research Fund of Sichuan Provincial People's Hospital 2017QN02
6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) is the leading cause of blindness in the elderly population, and Dry AMD is the most common clinical subtype. However, effective measures for the early diagnosis and treatment of dry AMD have not been proposed. In recent years, NOD-like receptors (NLRs) have received attention in the study of AMD as an important class of pattern recognition receptors. We attempted to elucidate the pathogenesis of NLRs in dry AMD from the perspective of chronic inflammation.

methodsThis study involved 13 patients with dry AMD, 10 age- and sex-matched normal population without any history of disease and 8 patients with wet AMD as controls. Using RT-qPCR, the mRNA expression levels of NLRs in peripheral blood peripheral blood mononuclear cells (PBMCs) were compared to analyze the statistical differences in the expression contents among the three populations.

resultsThe relative RNA expression of nucleotide-binding oligomerization-like receptor protein 12 (NLRP12) with negative regulation of inflammation was significantly lower in dry AMD patients than in normal people and wet AMD patients. And NLRX1, which also has an anti-inflammatory effect, was lower in dry AMD patients than in wet AMD patients. However, NLRP3 with proinflammatory effect was significantly expressed in wet AMD.

conclusionThe significant decrease in NLRP12 in dry AMD may become a breakthrough in the study of dry AMD and systemic chronic inflammatory response. However, NLRP3 may have a more important role in wet AMD.

Indexed as

Geographic AtrophyNLR Family, Pyrin Domain-Containing 3 ProteinWet Macular DegenerationAgedHumansInflammationIntracellular Signaling Peptides and ProteinsLeukocytes, MononuclearMitochondrial ProteinsIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP12 protein, humanNLRX1 protein, humanDry age-related macular degenerationNLRP12NLRP3NOD-like receptorsPathogenesis

Identifiers

PMID37936001
OpenAlexW4388478889

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.