Evidence map›Paper›PMID 37935987›Full record

ArticleCerebellum (London, England)2024

Relationship of Morphometrics and Symptom Severity in Female Type I Chiari Malformation Patients with Biological Resilience.

Mohamad Motaz Al Samman, Monica A Garcia, Maitane García, James R Houston, Dorothy Loth, Richard Labuda, Sarel Vorster, Petra M Klinge, Francis Loth, Douglas L Delahanty and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohamad Motaz Al SammanDepartment of Bioengineering, Northeastern University, Boston, MA, USA.
Monica A GarciaDepartment of Psychological Sciences, Kent State University, Kent, OH, USA.
Maitane GarcíaDepartment of Psychology, Faculty of Health Sciences, Neuro-E-Motion Research Team, University of Deusto, Bilbao, Spain.
James R HoustonDepartment of Psychology, Middle Tennessee State University, Murfreesboro, TN, USA.
Dorothy LothConquer Chiari Research Center, Northeastern University, Boston, MA, USA.
Richard LabudaConquer Chiari, Wexford, PA, USA.
Sarel VorsterDepartment of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Petra M KlingeDepartment of Neurosurgery, Rhode Island Hospital, Warren Alpert Medical School Brown University, Providence, RI, USA.
Francis LothDepartment of Mechanical and Industrial Engineering, Department of Bioengineering, Northeastern University, Boston, MA, USA.
Douglas L DelahantyDepartment of Psychological Sciences, Kent State University, Kent, OH, USA.
Philip A AllenDepartment of Psychology, Conquer Chiari Research Center, University of Akron, Akron, OH, USA. paallen@uakron.edu.

Funding

Novel MR Image Processing as an Objective Diagnostic Test for Chiari MalformationR15NS109957 · NINDS · UNIVERSITY OF AKRON · PI ALLEN, PHILIP A. · 2019 to 2019
$469k
NINDS and Conquer Chiari NINDS R15 Grant No. 1R15NS109957-01A1NINDS NIH HHS R15 NS109957
6 · The paper itself

Abstract

In the present study we report the relationship among MRI-based skull and cervical spine morphometric measures as well as symptom severity (disability-as measured by Oswestry Head and Neck Pain Scale and social isolation-as measured by the UCLA Loneliness scale) on biomarkers of allostatic load using estrogen, interleukin-6, C-reactive protein, and cortisol in a sample of 46 CMI patients. Correlational analyses showed that McRae line length was negatively associated with interleukin-6 and C-reactive protein levels, and Analysis of Variance (ANOVA) showed joint effects of morphometric measures (McRae line length, anterior CSF space) and symptom severity (disability and loneliness) on estrogen and intereukin-6 levels. These results are consistent with allostatic load. That is, when the combination of CSF crowding and self-report symptom (disability and loneliness) severity exceed the capacity of biological resilience factors, then biomarkers such as neuroprotective estrogen levels drop, rather than rise, with increasing symptom severity.

Indexed as

Arnold-Chiari MalformationMagnetic Resonance ImagingAdultBiomarkersC-Reactive ProteinEstrogensFemaleHumansHydrocortisoneInterleukin-6Middle AgedResilience, PsychologicalSeverity of Illness IndexYoung AdultBiomarkersC-Reactive ProteinEstrogensHydrocortisoneInterleukin-6Allostatic loadAnd disabilityBiomarkersChiari malformation Type ILonelinessMorphometrics

Identifiers

PMID37935987
PMCPMC12577350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.