ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024
Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder.Translational psychiatry · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Altered Brain Dynamics in Heavy Smokers Revealed by Dynamic Functional Network Connectivity Analysis.Brain topography · 2026Article
- Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics.NPJ science of learning · 2025Article
- Understanding Altered Dynamics in Cocaine Use Disorder Through State Transitions Mediated by Artificial Perturbations.Brain sciences · 2025Article
- Rest-Activity Rhythms, Their Modulators, and Brain-Clinical Correlates in Opioid Use Disorder.JAMA network open · 2025Article
- Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder.JAMA network open · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Substance use disorder (SUD) is a chronic relapsing disorder with long-lasting changes in brain intrinsic networks. While most research to date has focused on static functional connectivity, less is known about the effect of chronic drug use on dynamics of brain networks. Here we investigated brain state dynamics in individuals with opioid use (OUD) and alcohol use disorder (AUD) and assessed how concomitant nicotine use, which is frequent among individuals with OUD and AUD, affects brain dynamics. Resting-state functional magnetic resonance imaging data of 27 OUD, 107 AUD, and 137 healthy participants were included in the analyses. To identify recurrent brain states and their dynamics, we applied a data-driven clustering approach that determines brain states at a single time frame. We found that OUD and AUD non-smokers displayed similar changes in brain state dynamics including decreased fractional occupancy or dwell time in default mode network (DMN)-dominated brain states and increased appearance rate in visual network (VIS)-dominated brain states, which were also reflected in transition probabilities of related brain states. Interestingly, co-use of nicotine affected brain states in an opposite manner by lowering VIS-dominated and enhancing DMN-dominated brain states in both OUD and AUD participants. Our finding revealed a similar pattern of brain state dynamics in OUD and AUD participants that differed from controls, with an opposite effect for nicotine use suggesting distinct effects of various drugs on brain state dynamics. Different strategies for treating SUD may need to be implemented based on patterns of co-morbid drug use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.