ReviewNature reviews. Chemistry2023
Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics.
Review in Nature reviews. Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Dinitrogen Activation with Low-Valent Strontium.Angewandte Chemie (International ed. in English) · 2025Article
- Synthesis, characterization and reactivity of a series of alkaline earth and rare earth iminophosphoranomethanide complexes.Communications chemistry · 2025Article
- Synthesis of Heteroleptic Amidinato Calcium Halides via the In-Situ Grignard Addition Method (iGAM) Complementing the Metalation of Amidines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Exploring the Nuclearity and Structural Motifs of Phenoxyimine Alkaline Earth Complexes.Organometallics · 2025Article
- Fresh Impetus in the Chemistry of Calcium Peroxides.Journal of the American Chemical Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than a century old, magnesium Grignard reagents remain essential to the toolbox of organic chemists. Although similar reagents with the neighbouring group 2 metal Ca have been explored, the considerably higher polarity and reactivity of the Ca-C bond result in undesired decomposition pathways. Ca Grignard reagents have found academic interest but have never fully developed into an established synthetic tool. Recent research activities, however, provide facile access to these highly reactive organocalcium species, including in situ preparation and ball milling approaches to tackle the challenge of controlling their extreme sensitivity. Heavier Grignard reagents are not just more reactive but profit from unique chemical transformations. Insight into the transition metal-like properties of Ca, Sr and Ba is only just emerging. Considering the rapidly developing field of alkaline-earth metal-mediated catalysis, heavy Grignard reagents will probably have a bright future.
Identifiers
37935796What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.