Eigenmode-based approach reveals a decline in brain structure-function liberality across the human lifespan.

While brain function is supported and constrained by the underlying structure, the connectome-based link estimated by current approaches is either relatively moderate or accompanied by high model complexity, with the essential principles underlying structure-function coupling remaining elusive. Here, by proposing a mapping method based on network eigendecomposition, we present a concise and strong correspondence between structure and function. We show that the explanation of functional connectivity can be significantly improved by incorporating interactions between different structural eigenmodes. We also demonstrate the pronounced advantage of the present mapping in capturing individual-specific information with simple implementation. Applying our methodology to the human lifespan, we find that functional diversity decreases with age, with functional interactions increasingly dominated by the leading functional mode. We also find that structure-function liberality weakens with age, which is driven by the decreases in functional components that are less constrained by anatomy, while the magnitude of structure-aligned components is preserved. Overall, our work enhances the understanding of structure-function coupling from a collective, connectome-oriented perspective and promotes a more refined identification of functional portions relevant to human aging, holding great potential for mechanistic insights into individual differences associated with cognition, development, and neurological disorders.