Evidence map›Paper›PMID 37935477›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study.

Yiding Han, Haohao Yan, Xiaoxiao Shan, Huabing Li, Feng Liu, Ping Li, Jingping Zhao, Wenbin Guo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yiding Han *From the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Haohao Yan *From the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Xiaoxiao ShanFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Huabing LiFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Feng LiuFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Ping LiFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Jingping ZhaoFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li).
Wenbin GuoFrom the Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Han, Yan, Shan, Zhao, Guo); the Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (H. Li); the Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Liu); the Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China (P. Li) guowenbin76@csu.edu.cn.
Qiqihar Medical University · CNCentral South University · CNSecond Xiangya Hospital of Central South University · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired functional connectivity between the bilateral hemispheres may serve as the neural substrate for anxiety and depressive disorders, yet its role in comorbid generalized anxiety disorder (GAD) and depression, as well as the effect of treatment on this connectivity, remains unclear. We sought to examine functional connectivity between homotopic regions of the 2 hemispheres (voxel-mirrored homotopic connectivity [VMHC]) among people with GAD with and without comorbid depression at baseline and after a 4-week paroxetine treatment.

methodsDrug-naïve patients with GAD, with or without comorbid depression and healthy controls underwent functional magnetic resonance imaging and clinical assessments at baseline and after treatment. We compared VMHC and seed-based functional connectivity across the 3 groups. We performed correlation analysis and support vector regression (SVR) to examine the intrinsic relationships between VMHC and symptoms.

resultsBoth patient groups ( LIMITATIONS: A notable dropout rate and intergroup somatic symptom variations may have biased the results.

conclusionPatients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.

Indexed as

Cognitive DysfunctionMagnetic Resonance ImagingAnxietyAnxiety DisordersBrain MappingDepressionFollow-Up StudiesHumans

Identifiers

PMID37935477
PMCPMC10635709
OpenAlexW4388455000

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.