Evidence map›Paper›PMID 37935475›Full record

Trial reportJournal of psychiatry & neuroscience : JPN

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.

Siyu Liu, Hui Zhong, Yinfeng Qian, Huanhuan Cai, Yan-Bin Jia, Jiajia Zhu

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Siyu Liu *From the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong).
Hui Zhong *From the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong).
Yinfeng QianFrom the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong).
Huanhuan CaiFrom the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong).
Yan-Bin JiaFrom the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong) zhujiajiagraduate@163.com Yanbinjia2006@163.com.
Jiajia ZhuFrom the Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China (Liu, Qian, Cai, Zhu); the Research Center of Clinical Medical Imaging, Anhui Province, Hefei, China (Liu, Qian, Cai, Zhu); the Anhui Provincial Institute of Translational Medicine, Hefei, China (Liu, Qian, Cai, Zhu); the Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China (Zhong, Jia); the Department of Child and Adolescent Psychology, Anhui Mental Health Center, Hefei, China (Zhong); and the Hefei Fourth People's Hospital, Hefei, China (Zhong) zhujiajiagraduate@163.com Yanbinjia2006@163.com.
First Affiliated Hospital of Anhui Medical University · CNAnhui Medical University · CNAnhui Mental Health Center · CNAnhui Provincial Hospital · CNThird People's Hospital of Hefei · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychosocial interventions have emerged as an important component of a comprehensive therapeutic approach in early-onset schizophrenia, typically representing a more severe form of the disorder. Despite the feasibility and efficacy of Theory of Mind (ToM) psychotherapy for schizophrenia, relatively little is known regarding the neural mechanism underlying its effect on early-onset schizophrenia.

methodsWe performed a randomized, active controlled trial in patients with early-onset schizophrenia, who were randomly allocated into either an intervention (ToM psychotherapy) or an active control (health education) group. Diffusion tensor imaging data were collected to construct brain structural networks, with both global and regional topological properties measured using graph theory.

resultsWe enrolled 28 patients with early-onset schizophrenia in our study. After 5 weeks of treatment, both the intervention and active control groups showed significant improvement in psychotic symptoms, yet the improvement was greater in the intervention group. Importantly, in contrast with no brain structural network change after treatment in the active control group, the intervention group showed increased nodal centrality of the left insula that was associated with psychotic symptom improvement. LIMITATIONS: We did not collect important information concerning the participants' cognitive abilities, particularly ToM performance.

conclusionThese findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.

Indexed as

SchizophreniaTheory of MindDiffusion Tensor ImagingHumansPsychotherapySocial Perception

Identifiers

PMID37935475
PMCPMC10635708
OpenAlexW4388454650

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.