ArticleMolecular biology and evolution2023
Evolution of the Spider Homeobox Gene Repertoire by Tandem and Whole Genome Duplication.
Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio.Molecular biology and evolution · 2026Article
- Single-cell sequencing reveals potential novel insights into appendage-patterning and joint-development in a spider.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Conserved and diverged embryonic expression patterns of panarthropod NK-Cluster genes and new evidence for CRE-shuffling.BMC ecology and evolution · 2026Article
- Developmental system drift in the patterning of the arthropod tarsus.Proceedings. Biological sciences · 2026Article
- An ancient genome duplication event drives the development and evolution of spinnerets in spiders.Science advances · 2026Article
- Assessing the Impact of Whole Genome Duplication on Gene Expression and Regulation During Arachnid Development.Genome biology and evolution · 2025Article
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with a reduced posterior tagma.BMC biology · 2025Article
- Genome-wide quantitative dissection of an arthropod segmented body plan at single-cell resolution.Communications biology · 2025Article
- Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.PLoS biology · 2025Article
- Whole Genome Duplication in the Genomics Era: The Hidden Gems in Invertebrates?Genome biology and evolution · 2025Review
- Development and patterning of a highly versatile visual system in spiders.Proceedings. Biological sciences · 2025Article
- Article
- Three Novel Spider Genomes Unveil Spidroin Diversification and Hox Cluster Architecture: Ryuthela nishihirai (Liphistiidae), Uloborus plumipes (Uloboridae) and Cheiracanthium punctorium (Cheiracanthiidae).Molecular ecology resources · 2025Article
- Single-cell sequencing suggests a conserved function of Hedgehog-signalling in spider eye development.EvoDevo · 2024Article
- A taxon-restricted duplicate of Iroquois3 is required for patterning the spider waist.PLoS biology · 2024Article
- The genome sequence of the silver stretch spider,Wellcome open research · 2024Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Gene duplication generates new genetic material that can contribute to the evolution of gene regulatory networks and phenotypes. Duplicated genes can undergo subfunctionalization to partition ancestral functions and/or neofunctionalization to assume a new function. We previously found there had been a whole genome duplication (WGD) in an ancestor of arachnopulmonates, the lineage including spiders and scorpions but excluding other arachnids like mites, ticks, and harvestmen. This WGD was evidenced by many duplicated homeobox genes, including two Hox clusters, in spiders. However, it was unclear which homeobox paralogues originated by WGD versus smaller-scale events such as tandem duplications. Understanding this is a key to determining the contribution of the WGD to arachnopulmonate genome evolution. Here we characterized the distribution of duplicated homeobox genes across eight chromosome-level spider genomes. We found that most duplicated homeobox genes in spiders are consistent with an origin by WGD. We also found two copies of conserved homeobox gene clusters, including the Hox, NK, HRO, Irx, and SINE clusters, in all eight species. Consistently, we observed one copy of each cluster was degenerated in terms of gene content and organization while the other remained more intact. Focussing on the NK cluster, we found evidence for regulatory subfunctionalization between the duplicated NK genes in the spider Parasteatoda tepidariorum compared to their single-copy orthologues in the harvestman Phalangium opilio. Our study provides new insights into the relative contributions of multiple modes of duplication to the homeobox gene repertoire during the evolution of spiders and the function of NK genes.
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