Evidence map›Paper›PMID 37935047›Full record

ArticleEndocrinology2023

Evaluation of Ex Vivo Adrenocorticotropic Hormone Responsiveness of Human Fetal Testis.

Mariska A M Schröder, David Greenald, Renate Lodewijk, Antonius E van Herwaarden, Paul N Span, Fred C G J Sweep, Rod T Mitchell, Hedi L Claahsen-van der Grinten

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mariska A M SchröderDepartment of Pediatrics, Radboud Amalia Children's Hospital, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0003-2139-9076
David GreenaldMRC Centre for Reproductive Health, Institute for Regeneration and Repair, The University of Edinburgh, and the Royal Hospital for Children and Young People, Edinburgh EH16 4TJ, UK.
Renate LodewijkDepartment of Laboratory Medicine, Radboudumc Graduate School, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Antonius E van HerwaardenDepartment of Laboratory Medicine, Radboudumc Graduate School, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Paul N SpanDepartment of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboudumc Graduate School, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0002-1930-6638
Fred C G J SweepDepartment of Laboratory Medicine, Radboudumc Graduate School, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Rod T MitchellMRC Centre for Reproductive Health, Institute for Regeneration and Repair, The University of Edinburgh, and the Royal Hospital for Children and Young People, Edinburgh EH16 4TJ, UK.
Hedi L Claahsen-van der GrintenDepartment of Pediatrics, Radboud Amalia Children's Hospital, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0003-0181-0403
Radboud University Nijmegen · NLRoyal Hospital for Children · GB

Funding

Wellcome TrustWellcome Trust MR/006237/1
6 · The paper itself

Abstract

Testicular adrenal rest tumors (TARTs), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. It is not yet established whether the human fetal testis (HFT) is responsive to ACTH. To investigate this, we cultured HFT tissue with and without ACTH for up to 5 days, and quantified adrenal steroid hormones and expression of adrenal steroidogenic enzymes. Fetal testis and adrenal tissue produced high levels of testosterone and cortisol, respectively, indicating viability. In contrast to fetal adrenal tissues, the expression of ACTH receptor MC2R was either absent or expressed at extremely low levels in ex vivo HFT tissue and no clear response to ACTH in gene expression or steroid hormone production was observed. Altogether, this study suggests that the HFT is unresponsive to ACTH, which would indicate that a TART does not arise from fetal testicular cells chronically exposed to ACTH in utero.

Indexed as

Adrenal Hyperplasia, CongenitalTesticular NeoplasmsAdrenal GlandsAdrenocorticotropic HormoneHumansMaleSteroidsTestisAdrenocorticotropic HormoneSteroidsadrenocorticotropic hormonecongenital adrenal hyperplasiahuman fetal testistesticular adrenal rest tumors

Identifiers

PMID37935047
PMCPMC10652325
OpenAlexW4388447854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.