Evidence map›Paper›PMID 37934915›Full record

ArticleJournal of medicinal chemistry2023

Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization.

Umed Singh, Girija Pawge, Sarita Rani, Chia-Hung Christine Hsiao, Andrew J Wiemer, David F Wiemer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Umed SinghDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.
Girija PawgeDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Sarita RaniDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID 0000-0002-9037-027X
Andrew J WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID 0000-0002-3029-1780
David F WiemerDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.ORCID 0000-0002-4881-8544
University of Connecticut · USUniversity of Iowa · US

Funding

Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapyR01CA266138 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI ANDREW J WIEMER · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA266138
6 · The paper itself

Abstract

Activation of Vγ9Vδ2 T cells with butyrophilin 3A1 (BTN3A1) agonists such as (

Indexed as

OrganophosphonatesProdrugsButyrophilinsLigandsLymphocyte ActivationT-LymphocytesButyrophilinsLigandsOrganophosphonatesProdrugs

Identifiers

PMID37934915
PMCPMC10683022
OpenAlexW4388449054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.