ArticlePLoS genetics2023
Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.
Article in PLoS genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Differential DNA methylation in blood as potential mediator of the association between ambient PMMolecular psychiatry · 2026Article
- CpGene: a web application for epigenetic signature identification from DNA methylation arrays.Bioinformatics (Oxford, England) · 2026Article
- A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data.PLoS computational biology · 2026Article
- ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes.Statistics in medicine · 2026Article
- MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome.Genetic epidemiology · 2026Article
- Plasma proteome mediates the associations between air pollution exposure and disease risk.Nature communications · 2026Article
- Evaluating Methods for High-Dimensional Mediation in Metabolomics Data.Environmental science & technology · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic mediation may explain intergenerational associations between maternal obesogenic lifestyle and children's birth weight: findings from the NorthPop prospective birth cohort.Clinical epigenetics · 2025Article
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes.International journal of cancer · 2025Article
- Software Application Profile: TriplotGUI, a molecular epidemiology toolbox for investigating associations between exposures, omics, and outcomes.International journal of epidemiology · 2025Article
- High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application.Bioinformatics (Oxford, England) · 2025Article
- Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease.Epigenomics · 2025Review
- Debiased machine learning for ultra-high dimensional mediation analysis.Bioinformatics (Oxford, England) · 2025Article
- Multimedia: multimodal mediation analysis of microbiome data.Microbiology spectrum · 2025Article
- Neighborhood environment associations with cognitive function and structural brain measures in older African Americans.BMC medicine · 2025Article
- multimedia: Multimodal Mediation Analysis of Microbiome Data.bioRxiv : the preprint server for biology · 2024Article
- Network analysis identifies strain-dependent response to tau and tau seeding-associated genes.The Journal of experimental medicine · 2023Article
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Abstract
Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect of social/environmental exposures on a health outcome. Modern statistical methods for jointly evaluating many mediators have not been widely adopted. We compare seven methods for high-dimensional mediation analysis with continuous outcomes through both diverse simulations and analysis of DNAm data from a large multi-ethnic cohort in the United States, while providing an R package for their seamless implementation and adoption. Among the considered choices, the best-performing methods for detecting active mediators in simulations are the Bayesian sparse linear mixed model (BSLMM) and high-dimensional mediation analysis (HDMA); while the preferred methods for estimating the global mediation effect are high-dimensional linear mediation analysis (HILMA) and principal component mediation analysis (PCMA). We provide guidelines for epigenetic researchers on choosing the best method in practice and offer suggestions for future methodological development.
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