Evidence map›Paper›PMID 37934403›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023

In vitro combination with doxycycline plus antifungals against clinical Mucorales pathogens.

Meijie Zhang, Ge Song, Hailin Zheng, Balaji Pathakumari, Weida Liu, Guanzhao Liang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 4 countries.

Meijie ZhangDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China.
Ge SongDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China.
Hailin ZhengDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China.
Balaji PathakumariDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, 55901, USA.
Weida LiuDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China. liuwd@pumcderm.cams.cn.
Guanzhao LiangDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China. guanzhaoguan@126.com.ORCID http://orcid.org/0000-0002-5330-8864
Chinese Academy of Medical Sciences & Peking Union Medical College · CNMayo Clinic in Arizona · US

Funding

China National Key R&D Program during the 14th Five-year Plan Period 2022YFC2504804Chinese Academy of Medical Sciences Initiative for Innovative Medicine 2021-2IM-I-039
6 · The paper itself

Abstract

purposeSince systematic antifungals for mucormycosis showed variable MICs depending on strains, effective and safe antifungal therapy was still needed. This study is aimed to evaluate the in vitro activity of doxycycline combined with antifungal therapy against dominant Mucorales pathogens.

methodsMultidrug susceptibility testing was performed with doxycycline and antifungals, including itraconazole, posaconazole, and amphotericin, in 21 isolates of 8 dominant Mucorales pathogens.

resultsThe fractional inhibitory concentration index according to M38 showed one Rhizopus arrhizus isolate synergic (∑FICI = 0.375) and other isolates in addition (0.5 < ∑FICI < 4).

conclusionsDoxycycline was found to have in vitro advantages in combined antifungal treatment over antifungals alone.

Indexed as

Antifungal AgentsMucoralesAmphotericin BDoxycyclineItraconazoleMicrobial Sensitivity TestsAmphotericin BAntifungal AgentsDoxycyclineItraconazoleDoxycyclineMucor irregularisMucormycosisSusceptibility test

Identifiers

PMID37934403
PMCPMC10689593
OpenAlexW4388461132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.