Evidence map›Paper›PMID 37934383›Full record

Trial reportAnnals of surgical oncology2024

Effect of Preoperative Home-Based Exercise Training on Quality of Life After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial.

Pedro Machado, Sara Pimenta, Ana Luís Garcia, Tiago Nogueira, Sónia Silva, Claúdia Lares Dos Santos, Maria Vitória Martins, André Canha, Bárbara Oliveiros, Raul A Martins and 1 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07401056 (The Effect of Preoperative Structured Exercise Programme on Postoperative Pain Severity, Recovery Level, Discharge Time and Quality of Life in Patients With Non-Small Cell Lung Cancer), which is not on this map. Cited by 26 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07401056 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of Preoperative Structured Exercise Programme on Postoperative Pain Severity, Recovery Level, Discharge Time and Quality of Life in Patients With Non-Small Cell Lung Cancer: Randomised Controlled Study

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled62ConditionsNon-Small Cell Lung CancerArmsPrehabilitation (Structured Preoperative Exercise Programme)
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. The effectiveness of non-pharmacological interventions on sleep quality in lung cancer patients: a systematic review and meta-analysis (2015-2025).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Nonpharmacological dyspnoea-relief strategies in lung cancer: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
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  8. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  9. Pooled it
  10. Practical recommendations for exercise and nutrition in patients with lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Pedro MachadoCenter for Innovative Care and Health Technology (ciTechCare), School of Health Sciences of the Polytechnic of Leiria (ESSLei), Leiria, Portugal. pedro.machado@ipleiria.pt.
Sara PimentaCenter for Innovative Care and Health Technology (ciTechCare), School of Health Sciences of the Polytechnic of Leiria (ESSLei), Leiria, Portugal.
Ana Luís GarciaThoracic Surgery Unit, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.
Tiago NogueiraThoracic Surgery Unit, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.
Sónia SilvaPulmonology Department, Leiria Hospital Center, Leiria, Portugal.
Claúdia Lares Dos SantosPulmonology Department, District Hospital of Santarém, Santarém, Portugal.
Maria Vitória MartinsPulmonology Department, District Hospital of Figueira da Foz, Figueira da Foz, Portugal.
André CanhaPhysical Medicine and Rehabilitation Department, District Hospital of Santarém, Santarém, Portugal.
Bárbara OliveirosLaboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Raul A MartinsUniversity of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, Coimbra, Portugal.
Joana CruzCenter for Innovative Care and Health Technology (ciTechCare), School of Health Sciences of the Polytechnic of Leiria (ESSLei), Leiria, Portugal.

Funding

Portuguese Foundation for Science and Technology REF UIDB/05704/2020
6 · The paper itself

Abstract

backgroundPreoperative exercise training is recommended for improvement of clinical outcomes after lung cancer (LC) surgery. However, its effectiveness in preventing postoperative decline in quality of life (QoL) remains unknown. This study investigated the effect of preoperative home-based exercise training (PHET) on QoL after LC surgery.

methodsPatients awaiting LC resection were randomized to PHET or a control group (CG). The PHET program combined aerobic and resistance exercise, with weekly telephone supervision. Primary outcome was QoL-assessed with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQ-C30) at baseline, before surgery, and 1 month after surgery. The secondary outcomes were hospital length of stay and physical performance. The main analysis included a factorial repeated-measures analysis of variance. Additionally, the proportion of patients experiencing clinical deterioration from baseline to post-surgery was assessed.

resultsThe study included 41 patients (68.1 ± 9.3 years; 68.3% male) in the intention-to-treat analysis (20 PHET patients, 21 CG patients). A significant group × time interaction was observed for global QoL (p = 0.004). Between-group differences in global QoL were statistically and clinically significant before surgery (mean difference [MD], 13.5 points; 95% confidence interval [CI], 2.4-24.6; p = 0.019) and after surgery (MD, 12.4 points; 95% CI, 1.3-23.4; p = 0.029), favoring PHET. Clinical deterioration of global QoL was reported by 71.4% of the CG patients compared with 30 % of the PHET patients (p = 0.003). Between-group differences in favor of PHET were found in pain and appetite loss as well as in physical, emotional and role functions after surgery (p < 0.05). Compared with CG, PHET was superior in improving preoperative five-times sit-to-stand and postoperative exercise capacity (p < 0.05). No between-group differences in other secondary outcomes were observed.

conclusionThe study showed that PHET can effectively prevent the decline in QoL after LC surgery.

Indexed as

Clinical DeteriorationLung NeoplasmsExerciseFemaleHumansMalePreoperative ExerciseQuality of LifeHome-based exercise trainingLung cancerPrehabilitationQuality of lifeSurgical resection

Identifiers

PMID37934383
PMCPMC10761542

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.