ArticlePediatric nephrology (Berlin, Germany)2024
Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.
Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- COSMIC: a core outcome set for intravenous maintenance fluid therapy trials in children.World journal of pediatrics : WJP · 2026Pooled it
- European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3-fluid removal at de-escalation phase.Intensive care medicine · 2025Guideline
- Cryptic and Overt Acute Kidney Injury Share Biomarker Characteristics in Pediatric Acute Respiratory Distress Syndrome.Critical care explorations · 2026Observational
- Fluid balance and acute lung injury in children and young adults receiving continuous renal replacement therapy: a report from the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).European journal of pediatrics · 2026Article
- Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass.European journal of pediatrics · 2026Article
- Potential implications of subclinical hypervolemia, identified by a multiparametric approach, in causing left ventricular hypertrophy in clinically euvolemic children on dialysis: a prospective longitudinal pilot study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Outcomes and mortality risk in children with acute kidney injury requiring dialysis and mechanical ventilation: an observational study from a pediatric nephrology critical care unit.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.Critical care explorations · 2026Observational
- Extracorporeal membrane oxygenation, acute kidney injury, fluid balance, and continuous renal replacement therapy: Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) joint consensus conference.Intensive care medicine · 2026Article
- Bridging evidence and practice: implementation science and bundled care strategies for fluid management in critically ill neonates.Frontiers in medicine · 2026Article
- Barriers and opportunities to improve fluid balance recognition and reduction: a qualitative study.Frontiers in pediatrics · 2026Article
- The prognostic impact of net ultrafiltration intensity in critically ill patients receiving continuous renal replacement therapy: a multivariable and propensity-matched analysis.Renal failure · 2025Observational
- Are the outcomes of critically ill children undergoing pediatric continuous kidney replacement therapy actually modifiable?Pediatric nephrology (Berlin, Germany) · 2025Article
- Post-hurricane fluid conservation measures fail to reduce IV fluid use in critically ill children.Pediatric nephrology (Berlin, Germany) · 2025Article
- Challenges and strategies in ICU nursing for pediatric patients post-craniopharyngioma surgery: a narrative review.Translational pediatrics · 2025Review
- Identification of acute kidney injury in African children with severe malaria: a multinational individual participant data meta-analysis.Research square · 2025Article
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.medRxiv : the preprint server for health sciences · 2025Article
- Correlation between positive fluid balances with venous excess ultrasound scores and lung ultrasound in critically ill children with fluid overload.BMC pediatrics · 2025Article
- Functional outcomes in pediatric patients on renal replacement therapy in a worldwide registry.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundThe impact of disorders of fluid balance, including the pathologic state of fluid overload in sick children has become increasingly apparent. With this understanding, there has been a shift from application of absolute thresholds of fluid accumulation to an appreciation of the intricacies of fluid balance, including the impact of timing, trajectory, and disease pathophysiology.
methodsThe 26th Acute Disease Quality Initiative was the first to be exclusively dedicated to pediatric and neonatal acute kidney injury (pADQI). As part of the consensus panel, a multidisciplinary working group dedicated to fluid balance, fluid accumulation, and fluid overload was created. Through a search, review, and appraisal of the literature, summative consensus statements, along with identification of knowledge gaps and recommendations for clinical practice and research were developed.
conclusionsThe 26th pADQI conference proposed harmonized terminology for fluid balance and for describing a pathologic state of fluid overload for clinical practice and research. Recommendations include that the terms daily fluid balance, cumulative fluid balance, and percent cumulative fluid balance be utilized to describe the fluid status of sick children. The term fluid overload is to be preserved for describing a pathologic state of positive fluid balance associated with adverse events. Several recommendations for research were proposed including focused validation of the definition of fluid balance, fluid overload, and proposed methodologic approaches and endpoints for clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.