Evidence map›Paper›PMID 37934199›Full record

ArticleeLife2023

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

Denis Dacheux, Guillaume Martinez, Christine E Broster Reix, Julie Beurois, Patrick Lores, Magamba Tounkara, Jean-William Dupuy, Derrick Roy Robinson, Corinne Loeuillet, Emeline Lambert and 22 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 6 institutions in 4 countries.

Denis Dacheux *University of Bordeaux, CNRS, Bordeaux, France.
Guillaume Martinez *CHU Grenoble-Alpes, UM de Génétique Chromosomique, Grenoble, France.ORCID 0000-0002-7572-9096
Christine E Broster ReixUniversity of Bordeaux, CNRS, Bordeaux, France.
Julie BeuroisInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Patrick LoresInstitut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Cite, Paris, France.
Magamba TounkaraUniversity of Bordeaux, CNRS, Bordeaux, France.
Jean-William DupuyUniversité Bordeaux, Plateforme Protéome, Bordeaux, France.
Derrick Roy RobinsonUniversity of Bordeaux, CNRS, Bordeaux, France.ORCID 0000-0001-5572-4127
Corinne LoeuilletInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Emeline LambertInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Zeina WehbeInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Jessica EscoffierInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.ORCID 0000-0001-8166-5845
Amir Amiri-YektaDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Islamic Republic of Iran.
Abbas DaneshipourDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Islamic Republic of Iran.
Seyedeh-Hanieh HosseiniDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Islamic Republic of Iran.
Raoudha ZouariPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Selima Fourati Ben MustaphaPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Lazhar HalouaniPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Xiaohui JiangHuman Sperm Bank, West China Second University Hospital of Sichuan University, Sichuan, China.
Ying ShenNHC Key Laboratory of Chronobiology, Sichuan University, Sichuan, China.
Chunyu LiuObstetrics and Gynecology Hospital, Fudan University, Fudan, China.
Nicolas Thierry-MiegUniversité Grenoble Alpes, CNRS, Grenoble, France.
Amandine SeptierUniversité Grenoble Alpes, CNRS, Grenoble, France.
Marie BidartInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Véronique SatreCHU Grenoble-Alpes, UM de Génétique Chromosomique, Grenoble, France.
Caroline CazinCHU Grenoble-Alpes, UM de Génétique Chromosomique, Grenoble, France.
Zine Eddine KherrafInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Christophe ArnoultInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.ORCID 0000-0002-3753-5901
Pierre F RayInstitute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Aminata Toure *Institute for Advanced Biosciences, INSERM U 1209, CNRS UMR 5309, Université Grenoble Alpes, Team Physiology and Pathophysiology of Sperm cells, Grenoble, France.ORCID 0000-0001-5629-849X
Mélanie Bonhivers *University of Bordeaux, CNRS, Bordeaux, France.ORCID 0000-0001-9179-8473
Charles Coutton *Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.ORCID 0000-0002-8873-8098
Centre National de la Recherche Scientifique · FRCentre for Medically Assisted Procreation · CHRoyan Institute · IRSichuan University · CNCentre Hospitalier Universitaire de Grenoble · FRObstetrics and Gynecology Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility is common and complex, presenting a wide range of heterogeneous phenotypes. Although about 50% of cases are estimated to have a genetic component, the underlying cause often remains undetermined. Here, from whole-exome sequencing on samples from 168 infertile men with asthenoteratozoospermia due to severe sperm flagellum, we identified homozygous

Indexed as

AsthenozoospermiaInfertility, MaleAnimalsCalcium-Binding ProteinsDyneinsFertilityFlagellaHumansMaleMiceSemenCalcium-Binding ProteinsDNAH1 protein, humanDyneinsWDR66 protein, humanasthenoteratozoospermiaDNAH1geneticsgenomicshumanmale infertilitysperm flagellumTrypanosoma bruceiTTC29

Identifiers

PMID37934199
PMCPMC10629824
OpenAlexW4380323099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.