Evidence map›Paper›PMID 37933960›Full record

ArticleeLife2023

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in

Alex W Chan, Malgorzata Broncel, Eden Yifrach, Nicole R Haseley, Sundeep Chakladar, Elena Andree, Alice L Herneisen, Emily Shortt, Moritz Treeck, Sebastian Lourido

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024
    Article
  9. Proteomics Applications inPathogens (Basel, Switzerland) · 2023
    Review
  10. Article
  11. mBio · 2023
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alex W ChanWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-5444-5756
Malgorzata BroncelSignaling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0003-2991-3500
Eden YifrachWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0001-5074-0048
Nicole R HaseleyWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-9346-2161
Sundeep ChakladarWhitehead Institute for Biomedical Research, Cambridge, United States.
Elena AndreeWhitehead Institute for Biomedical Research, Cambridge, United States.
Alice L HerneisenWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0003-3368-0893
Emily ShorttWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0009-0009-7625-4772
Moritz TreeckSignaling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-9727-6657
Sebastian LouridoWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-5237-1095
The Francis Crick Institute · GBWhitehead Institute for Biomedical Research · US

Funding

Dissecting the calcium dependent phosphorylation network of Toxoplasma gondiiR01AI123457 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ARRIZABALAGA, GUSTAVO A, TREECK, MORITZ · 2016 to 2020
$2.7M
Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
Cancer Research UK CC0199Cancer Research UK CC2132Medical Research Council CC0199Medical Research Council CC2132NIAID NIH HHS R01 AI123457NIAID NIH HHS R01 AI144369NIH HHS R01AI123457NIH HHS R01AI144369Wellcome Trust CC0199Wellcome Trust CC2132
6 · The paper itself

Abstract

Apicomplexan parasites use Ca

Indexed as

ParasitesToxoplasmaAnimalsEndosomesExocytosisMicronemeOrganellesProtozoan ProteinsProtozoan ProteinsCDPKcell biologyhost–pathogen interactionsinfectious diseasemicrobiologysignalingToxoplasma gondiivesicular trafficking

Identifiers

PMID37933960
PMCPMC10629828
OpenAlexW4327587458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.