Evidence map›Paper›PMID 37933660›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Metformin alleviates pathologic pain in mice with radiation dermatitis by inhibiting p38MAPK/NF-κB signaling pathway].

J Cao, H Liu, Q An, F Han

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J CaoDepartment of Dermatology, Lianyungang Oriental Hospital, Lianyungang 222042, China.
H LiuDepartment of Dermatology, Lianyungang Oriental Hospital, Lianyungang 222042, China.
Q AnDepartment of Dermatology, Lianyungang Oriental Hospital, Lianyungang 222042, China.
F HanDepartment of Dermatology, Lianyungang Oriental Hospital, Lianyungang 222042, China.
Lianyungang Oriental Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the therapeutic effect of metformin on pathological pain in mice with radiation dermatitis and explore the underlying mechanism.

methodsThirty-two male adult ICR mice were randomized into normal control group, radiation dermatitis model group, metformin treatment (200 mg/kg) group and gabapentin (100 mg/kg) group (

resultsCompared with those in the control group, the mice in the other 3 groups showed obvious symptoms of radiation dermatitis after modeling (

conclusionMetformin can significantly ameliorate pathological pain symptoms in mice with radiation dermatitis possibly by inhibiting the activation of p38MAPK/NF-κB signaling pathway.

Indexed as

MAP Kinase Signaling SystemMetforminNF-kappa BRadiodermatitisAnimalsGabapentinInterleukin-6MaleMiceMice, Inbred ICRPainRadiation Injuries, ExperimentalTumor Necrosis Factor-alphaGabapentinInterleukin-6MetforminNF-kappa BTumor Necrosis Factor-alphametforminnuclear factor-κBp38MAPKpathological painradiation dermatitis

Identifiers

PMID37933660
PMCPMC10630197
OpenAlexW4388466786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.