Evidence map›Paper›PMID 37933655›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[HIF-1α activation induces cholesterol homeostasis dysfunction to accelerate progression of diabetic nephropathy in rats].

Y Wang, M Zhou, Q Zhu, C Zhang, L Wang, S Li, Z Hu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Y WangDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
M ZhouSchool of Clinical Medicine, Wannan Medical College, Wuhu 241002, China.
Q ZhuDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
C ZhangDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
L WangDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
S LiDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
Z HuDepartment of Pathophysiology, School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.
Wannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of hypoxia inducible factor-1α (HIF-1α) activation on cholesterol homeostasis dysfunction in diabetic nephropathy (DN).

methodsRat models of type 1 diabetes established by intraperitoneal STZ injection were treated with intraperitoneal injection of Lificiguat (YC-1, a HIF-1α inhibitor). Human proximal tubular cell line HK-2 was incubated with cobalt chloride (CoCl

resultsThe diabetic rats showed significantly increased 24-h urinary protein level (

conclusionHIF-1α activation induces cholesterol homeostasis dysregulation possibly by upregulating the de novo synthesis and uptake of cholesterol, thereby aggravating tubulointerstitial injury in DN.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesHypoxia-Inducible Factor 1, alpha SubunitAnimalsCobaltGlucoseHomeostasisHumansRatsTransforming Growth Factor beta1Cobaltcobaltous chlorideGlucoseHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitTransforming Growth Factor beta1cholesteroldiabetic nephropathyhypoxia inducible factor-1αlipid accumulationtubules

Identifiers

PMID37933655
PMCPMC10630203
OpenAlexW4388466166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.