Evidence map›Paper›PMID 37933649›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[High expression of RAB7A is associated with poor prognosis of gastric cancer by promoting tumor invasion].

M Zhang, S Liu, N Zhang, W Zhang, Y Xia, X Song, X Zhang, L Zuo, J Li, J Hu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M ZhangClinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
S LiuSchool of Laboratory Medicine, Bengbu Medical College, Bengbu 233000, China.
N ZhangClinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
W ZhangClinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
Y XiaDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
X SongCentral Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
X ZhangCentral Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
L ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
J LiClinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
J HuClinical Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
Bengbu Medical College · CNFirst Affiliated Hospital of Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the expression level of Ras-related protein 7A (RAB7A) in gastric cancer and its prognostic implications.

methodsBased on data from public databases and a cohort of 104 patients undergoing radical gastrectomy for gastric cancer in our hospital, we analyzed RAB7A expression level in gastric cancer and adjacent tissues and its association with clinicopathological parameters and prognosis of the patients. Bioinformatic analysis was performed to predict the pathways of RAB7A to affect gastric cancer invasion. In gastric cancer MGC803 cells with lentivirus-mediated interference or overexpression of RAB7A, the changes in extracellular matrix (ECM) degradation and cell migration and invasion were analyzed using immunoblotting, wound healing assay and Transwell experiments.

resultsThe data from public cancer databases and clinical samples showed a significantly higher expression of RAB7A in gastric cancer tissues than in normal or adjacent tissues (

conclusionRAB7A is highly expressed in gastric cancer tissues and affects the patients' prognosis possibly by activating the PI3K/AKT signaling pathway and enhancing ECM degradation to promote tumor invasion.

Indexed as

Stomach NeoplasmsCell Line, TumorCell MovementCell ProliferationHumansPhosphatidylinositol 3-KinasesPrognosisProto-Oncogene Proteins c-aktSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktgastric cancerinvasionPI3K/AKTprognosisRas-related protein 7A

Identifiers

PMID37933649
PMCPMC10630196
OpenAlexW4388466636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.