Evidence map›Paper›PMID 37933648›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Quercetin induces hepatic stellate cell apoptosis by inhibiting the PI3K/Akt signaling pathway

X Gao, X Zhao, C Zhang, Y Yan, R Jin, Y Ma

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

X GaoDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
X ZhaoDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
C ZhangDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
Y YanDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
R JinDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
Y MaDepartment of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether quercetin induces apoptosis of hepatic stellate cells by regulating miR-146 to inhibit the PI3K/Akt signaling pathway.

methodsRat hepatic stellate cells (HSC-T6) were treated with TGF-β and different concentrations (40, 60 and 80 μmol/L) of quercetin, and the changes in cell proliferation and apoptosis were detected using CCK-8 assay and flow cytometry. RT-qPCR was used to detect the expression of miR-146 and mRNA expressions of

resultsTreatment with quercetin dose- and time-dependently inhibited the proliferation of HSC-T6 cells and significantly increased the total cell apoptosis rate (

conclusionQuercetin inhibits proliferation and promotes apoptosis of HSCs by upregulating miR-146 to inhibit the PI3K/Akt signaling pathway.

Indexed as

MicroRNAsProto-Oncogene Proteins c-aktAnimalsApoptosisCell ProliferationHepatic Stellate CellsPhosphatidylinositol 3-KinasesQuercetinRatsRNA, MessengerSignal TransductionTNF Receptor-Associated Factor 6Transforming Growth Factor betaMicroRNAsMIRN146 microRNA, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuercetinRNA, MessengerTNF Receptor-Associated Factor 6Transforming Growth Factor betahepatic stellate cellsmiR-146PI3K/Akt signaling pathwayquercetin

Identifiers

PMID37933648
PMCPMC10630198
OpenAlexW4388466303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.