Evidence map›Paper›PMID 37933447›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer.

Rashi Singhal, Nikhil Kumar Kotla, Sumeet Solanki, Wesley Huang, Hannah N Bell, Marwa O El-Derany, Cristina Castillo, Yatrik M Shah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rashi SinghalDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-2685-5667
Nikhil Kumar KotlaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Sumeet SolankiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Wesley HuangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Hannah N BellDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Marwa O El-DeranyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Cristina CastilloDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-2487-4816
University of Michigan · USAin Shams University · EG

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Control of iron absorption by intestinal HIF2 in iron and hematological disordersR01DK095201 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2012 to 2025
$5.7M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Understanding the mechanisms of iron addiction in colon cancerR01CA245546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2020 to 2024
$2.3M
The role of lipid reprogramming in ferroptotic cell death in inflammatory bowel disease (IBD)F30DK131851 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, WESLEY WEIQIAO · 2022 to 2023
$80k
Defining the role of microenvironmental ammonia in colorectal cancersF30CA257292 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BELL, HANNAH NOELLE · 2021 to 2022
$40k
NCI NIH HHS F30 CA257292NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA245546NIDDK NIH HHS F30 DK131851NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK095201NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Neutrophils are abundant immune cells in the colon tumor microenvironment. Studies have shown that neutrophils are recruited into hypoxic foci in colon cancer. However, the impact of hypoxia signaling on neutrophil function and its involvement in colon tumorigenesis remain unclear. To address this, we generated mice with a deletion of hypoxia-inducible factor (HIF)-1α or HIF-2α in neutrophils driven by the MRP8Cre (

Indexed as

Colitis-Associated NeoplasmsColonic NeoplasmsAnimalsBasic Helix-Loop-Helix ProteinsBody WeightCarcinogenesisCell Transformation, NeoplasticCytokinesEndothelial PAS Domain-Containing Protein 1HypoxiaHypoxia-Inducible Factor 1, alpha SubunitInflammationMiceNeutrophilsTumor MicroenvironmentBasic Helix-Loop-Helix ProteinsCytokinesEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor 1, alpha Subunitcolitiscolorectal cancerHIF-2αinflammationneutrophil

Identifiers

PMID37933447
PMCPMC11208019
OpenAlexW4388462764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.