Evidence map›Paper›PMID 37933193›Full record

ArticleThe journal of sexual medicine2023

Urinary symptoms and female sexual dysfunction in women with type 1 diabetes: the role of depression.

Golena Fernandez Moncaleano, Cody M Gibbons, Sarah Holt, Barbara Braffett, Rodica Pop-Busui, Alan Jacobson, Hunter Wessells, Aruna Sarma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of sexual medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Golena Fernandez MoncaleanoDepartment of Urology, University of Michigan, Ann Arbor, MI 48109-2800, United States.
Cody M GibbonsDepartment of Urology, Virginia Mason Medical Center, Seattle, WA 98101, United States.
Sarah HoltDepartment of Urology and Diabetes Endocrinology Research Center, University of Washington, Seattle, WA 98195, United States.
Barbara BraffettBiostatistics Center, George Washington University, Rockville, MD 20852, United States.
Rodica Pop-BusuiDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, United States.
Alan JacobsonLong Island School of Medicine, New York University, Mineola, NY 11501, United States.
Hunter WessellsDepartment of Urology and Diabetes Endocrinology Research Center, University of Washington, Seattle, WA 98195, United States.
Aruna SarmaDepartment of Urology, University of Michigan, Ann Arbor, MI 48109-2800, United States.
University of Michigan–Ann Arbor · USUniversity of Washington · USGeorge Washington University · USMichigan Medicine · USNew York University · USVirginia Mason Medical Center · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
University of Michigan UroEPI Career Development ProgramK12DK111011 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN, SARMA, ARUNA V · 2016 to 2025
$3.6M
Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- DiabetesR01DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2009 to 2013
$2.7M
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesR01DK116723 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2021 to 2024
$2.5M
NEI NIH HHSNIDDK NIH HHS 5R01-DK-083927NIDDK NIH HHS K12 DK111011NIDDK NIH HHS P30 DK092926NIDDK NIH HHS R01 DK083927NIDDK NIH HHS R01 DK116723NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176NIH HHS
6 · The paper itself

Abstract

backgroundSome reports suggest that women with type 1 diabetes (T1D) have a greater burden of female sexual dysfunction (FSD) than women without T1D, but the etiology of this elevated risk is poorly understood.

aimTo examine the associations between FSD and urinary incontinence/lower urinary tract symptoms (UI/LUTS) in women with T1D and to evaluate how depression may mediate these relationships.

methodsLUTS and UI symptoms were assessed in women with T1D who participated in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Multivariable logistic regression models estimated associations between FSD and UI/LUTS (overall and specific domains) and the impact of depression on these associations. OUTCOMES: FSD was measured with the Female Sexual Function Index-Reduced.

resultsIn total, 499 self-reported sexually active women completed validated assessments of sexual and urinary function (mean ± SD age, 47.7 ± 7.6 years; T1D duration, 23.4 ± 5.15 years). FSD was reported in 232 (46%) responders. The frequency of UI and LUTS was 125 (25.1%) and 96 (19.2%), respectively. Neither UI nor its subcategories (urge, stress) were associated with FSD. Although LUTS (odds ratio [OR], 1.75; 95% CI, 1.09-2.77) and its symptoms of urgency (OR, 1.99; 95% CI, 1.09-3.61) and incomplete emptying (OR, 2.44; 95% CI, 1.23-4.85) were associated with FSD, these associations were attenuated following adjustment for depression and antidepressant medication use. Depression indicators were independently associated with FSD overall and across domains. CLINICAL IMPLICATIONS: The complex interplay of voiding dysfunction, mental health, and sexual function warrants further investigation to understand the potential implications for patient assessment, goal setting, treatment, and care planning. STRENGTHS AND LIMITATIONS: Data are from a prospective study of individuals with T1D. These results are unable to explore cause-and-effect relationships among LUTS, UI, depression, and FSD. The sample may not be representative of the general population of women with T1D. Because participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study are mostly White, generalizing the findings to other races and to type 2 diabetes may not be appropriate. While exclusion of sexually inactive women likely biases our findings toward the null, this design element permitted study of LUTS and UI in relation to aspects of FSD, the primary objective of this study.

conclusionsThe significant associations between LUTS/UI and FSD among middle-aged women with T1D were greatly attenuated when depression was considered a mediating factor.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Urinary IncontinenceAdultDepressionFemaleHumansMiddle AgedProspective Studies

Identifiers

PMID37933193
PMCPMC10689960
OpenAlexW4388459544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.