Evidence map›Paper›PMID 37932761›Full record

ArticleBMC complementary medicine and therapies2023

The effect of lavender aroma for anxiety disorder: a study protocol for a multicenter, double-masked, randomized, placebo-controlled clinical trial.

Haruka Amitani, Ryusei Nishi, Kenichiro Sagiyama, Takamasa Fukumoto, Kouta Funakoshi, Naomi Takayanagi, Hiroko Watanabe, Masayuki Hirose, Koshiro Tagawa, Keiko Ota and 2 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haruka AmitaniDepartment of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Ryusei Nishi *Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kenichiro Sagiyama *Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Takamasa FukumotoDepartment of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kouta FunakoshiCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Naomi TakayanagiCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Hiroko WatanabeCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Masayuki HiroseCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Koshiro TagawaCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Keiko OtaCenter for Clinical Research and Innovation, Osaka City University Hospital, Osaka, Japan.
Yoichi M ItoData Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan.
Akihiro AsakawaDepartment of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. asakawa@m2.kufm.kagoshima-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP18lk0310047
6 · The paper itself

Abstract

backgroundAnxiety disorder is the most prevalent psychiatric disorder. Benzodiazepines, which are often used for anxiety in patients with anxiety disorder, have various side effects. Lavender, one of the most commonly used essential oils in aromatherapy, has the potential to reduce benzodiazepine use for anxiety disorders.

methodsThis study is a multicenter, double-masked, randomized, placebo-controlled clinical trial. The study will recruit patients aged 20-59 years old with generalized anxiety disorder and panic disorder among anxiety disorders. The bottle containing the test solution (lavender aroma essential oil or distilled water) will be given to the patients. Patients will carry the bottles with them in their daily life and use the drops on tissue paper when anxious. The primary endpoint is the number of times anxiolytics used in 28 days. DISCUSSION: If the use of benzodiazepines could be reduced by sniffing lavender aroma, which is inexpensive and safe, it would contribute not only to the risks associated with benzodiazepine use but also to the health care economy and could even be added as a standard treatment.

trial registrationUniversity hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), ID: UMIN000034422 Registered 17 January 2019.

Indexed as

AromatherapyLavandulaAdultAnxiety DisordersBenzodiazepinesHumansMiddle AgedMulticenter Studies as TopicOdorantsRandomized Controlled Trials as TopicYoung AdultBenzodiazepinesA multicenterAnxiety disorderAromatherapyDouble-maskedPlacebo-controlled clinical trialRandomizedSniffing lavender aromaStudy protocol

Identifiers

PMID37932761
PMCPMC10626714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.