ArticleBMC public health2023
Influence of social deprivation on morbidity and all-cause mortality of cardiometabolic multi-morbidity: a cohort analysis of the UK Biobank cohort.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.Nutrients · 2026Article
- The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- The association between depression, anxiety, sleep disturbances and dementia: a prospective cohort study of 350,186 adults.BMC neurology · 2026Article
- Risk prediction of cardiometabolic diseases with depression in the community of Xinjiang production and construction corps.BMC public health · 2025Article
- Prevalence and factors associated with cardiometabolic multimorbidity: a cross-sectional study in older adults of the first Brazilian hypertension registry.BMC cardiovascular disorders · 2025Article
- The impact of artificial intelligence on biomarker discovery.Emerging topics in life sciences · 2025Article
- Trends, Social Determinants, and Lifestyle Factors Associated With Comorbidity of Diabetes and Kidney Diseases Among Chinese Adults Aged ≥ 45 Years.Journal of diabetes · 2025Observational
- Neighbourhood deprivation and cardiometabolic outcomes in the UK Biobank: differences by sex and ethnicity.Open heart · 2025Article
- Association between Dietary Patterns and Cardiometabolic Multimorbidity among Chinese Rural Older Adults.Nutrients · 2024Article
- Relative Deprivation and Health Among Chinese Adults: The Mediating Role of Subjective Well-Being.Inquiry : a journal of medical care organization, provision and financingArticle
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Abstract
backgroundThe relation of social deprivation with single cardiometabolic disease (CMD) was widely investigated, whereas the association with cardiometabolic multi-morbidity (CMM), defined as experiencing more than two CMDs during the lifetime, is poorly understood.
methodsWe analyzed 345,417 UK Biobank participants without any CMDs at recruitment to study the relation between social deprivation and four CMDs including type II diabetes (T2D), coronary artery disease (CAD), stroke and hypertension. Social deprivation was measured by Townsend deprivation index (TDI), and CMM was defined as occurrence of two or more of the above four diseases. Multivariable Cox models were performed to estimate hazard ratios (HRs) per one standard deviation (SD) change and in quartile (Q1-Q4, with Q1 as reference), as well as 95% confidence intervals (95% CIs).
resultsDuring the follow up, 68,338 participants developed at least one CMD (median follow up of 13.2 years), 16,225 further developed CMM (median follow up of 13.4 years), and 18,876 ultimately died from all causes (median follow up of 13.4 years). Compared to Q1 of TDI (lowest deprivation), the multivariable adjusted HR (95%CIs) of Q4 (highest deprivation) among participants free of any CMDs was 1.23 (1.20 ~ 1.26) for developing one CMD, 1.42 (1.35 ~ 1.48) for developing CMM, and 1.34 (1.27 ~ 1.41) for all-cause mortality. Among participants with one CMD, the adjusted HR (95%CIs) of Q4 was 1.30 (1.27 ~ 1.33) for developing CMM and 1.34 (1.27 ~ 1.41) for all-cause mortality, with HR (95%CIs) = 1.11 (1.06 ~ 1.16) for T2D patients, 1.07 (1.03 ~ 1.11) for CAD patients, 1.07 (1.00 ~ 1.15) for stroke patients, and 1.24 (1.21 ~ 1.28) for hypertension patients. Among participants with CMM, TDI was also related to the risk of all-cause mortality (HR of Q4 = 1.35, 95%CIs 1.28 ~ 1.43).
conclusionsWe revealed that people living with high deprived conditions would suffer from higher hazard of CMD, CMM and all-cause mortality.
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