ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2024
Cerebral autoregulation-based mean arterial pressure targets and delirium in critically ill adults without brain injury: a retrospective cohort study.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02344043 (Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness
Who cites it
9 citing papers in PubMed, 6 citations in OpenAlex.
- NIRS-assisted cerebral autoregulation in elderly patients during thoracic surgery: a prospective observational study.BMC anesthesiology · 2026Observational
- Silent Stroke in Adult Cardiac Surgery: Mechanisms, Clinical Impact, and Preventive Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Feasibility of Calculating and Maintaining Near-Infrared Spectroscopy-Guided Personalized Mean Arterial Pressure Targets in Adults With Critical Illness: A Pilot Clinical Study.Critical care explorations · 2026Article
- Regional Cerebral Oxygen Saturation and Risk of Delirium: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2025Review
- Optimal mean arterial pressure and its objective statistical associations with clinical outcomes and multimodal monitoring cerebral physiology: A systematic scoping review.Physiological reports · 2025Article
- Application of a Nomogram Model in Predicting Postoperative Delirium Following Percutaneous Coronary Intervention.Bioengineering (Basel, Switzerland) · 2025Article
- Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review.Critical care (London, England) · 2025Article
- Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy.Critical care explorations · 2024Observational
- In reply: Do endotracheal tubes with subglottic suction devices cause airway injury?Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCerebral autoregulation (CA) is a mechanism that acts to maintain consistent cerebral perfusion across a range of blood pressures, and impaired CA is associated with delirium. Individualized CA-derived blood pressure targets are poorly characterized in critically ill patients and the association with intensive care unit (ICU) delirium is unknown. Our objectives were to characterize optimal mean arterial pressure (MAP
methodsWe performed a retrospective cohort analysis of patients with shock of any etiology and/or respiratory failure requiring invasive mechanical ventilation, without a neurologic admitting diagnosis. Patients were screened daily for delirium. Cerebral oximetry and mean arterial pressure data were captured for the first 24 hr from enrolment.
resultsForty-two patients with invasive blood pressure monitoring data were analyzed. Optimal mean arterial pressure targets ranged from 55 to 100 mm Hg. Optimal mean arterial pressure values were not significantly different based on history of hypertension or delirium status, and delirium was not associated with deviations from MAP
conclusionWe observed that MAP STUDY REGISTRATION: ClinicalTrials.gov (NCT02344043); first submitted 22 January 2015.
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Registered trials
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