Evidence map›Paper›PMID 37932516›Full record

ArticleIn vitro cellular & developmental biology. Animal2023

Establishment of SLC7A11-knockout mouse and its preliminary investigation in melanoma.

Yang Chen, Tingting Lu, Yufei Liu, Yongqi Liu, Shaocheng Bai, Qiuran Chen, Bohao Zhao, Xinsheng Wu

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Redox pathways in melanoma.Advances in cancer research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yang ChenCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Tingting LuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Yufei LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Yongqi LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Shaocheng BaiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Qiuran ChenCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Bohao ZhaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Xinsheng WuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. xswu@yzu.edu.cn.ORCID http://orcid.org/0000-0001-9871-0251
Yangzhou University · CN

Funding

Innovation and Entrepreneurship Talent Project of Lanzhou Grant no. X20220652National Natural Science Foundation of China Grant no. 32172722
6 · The paper itself

Abstract

Solute carrier family 7 member 11 (SLC7A11)/xCT is an amino acid transporter that mediates the cystine uptake and glutamate export, participates in several malignant tumors' progression. However, the role of SLC7A11 on the occurrence and development of melanoma still remains unclear. Here, the transcribed mRNA encoding for Cas9 and sgRNA targeting SLC7A11 in vitro were microinjected into zygotes, to establish the SLC7A11 knockout (KO) mice (SLC7A11

Indexed as

Amino Acid Transport System y+MelanomaMelanoma, ExperimentalAnimalsCell LineCystineMiceMice, KnockoutRNA, Guide, CRISPR-Cas SystemsAmino Acid Transport System y+CystineRNA, Guide, CRISPR-Cas SystemsSlc7a11 protein, mouseCRISPR/Cas9KO miceMelanomaSLC7A11

Identifiers

PMID37932516
OpenAlexW4388407854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.