Evidence map›Paper›PMID 37932477›Full record

ReviewPathologie (Heidelberg, Germany)2023

[The two-in-one hit model of the short-cut carcinogenesis of colorectal carcinomas in MLH1-associated Lynch syndrome].

A Ahadova, A Stenzinger, T Seppälä, R Hüneburg, M Kloor, H Bläker

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Pathologie (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

A AhadovaAbteilung für Angewandte Tumorbiologie, Pathologisches Institut, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
A StenzingerPathologisches Institut, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
T SeppäläFaculty of Medicine and Health Technology, Tampere University, Tampere, Finnland.
R HüneburgNationales Zentrum für erbliche Tumorerkrankungen, Universitätsklinikum Bonn, Bonn, Deutschland.
M KloorAbteilung für Angewandte Tumorbiologie, Pathologisches Institut, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
H BläkerDepartment für Diagnostik, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Liebigstr. 26, 04103, Leipzig, Deutschland. hendrik.blaeker@medizin.uni-leipzig.de.
German Cancer Research Center · DETampere University · FIUniversity Hospital Bonn · DEUniversity Hospital Heidelberg · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recently published study a new genetic hypothesis was established that explained the existence of CTNNB1 mutations in Lynch syndrome-associated colorectal carcinomas (MLH1-LS-CRC). This hypothesis states that a mitotic recombination on chromosome 3p simultaneously leads to inactivation of the mismatch repair gene MLH1 and to the activation of CTNNB1. This explains the increased frequency of CTNNB1 mutations in MLH1-LS-CRC compared with other colon carcinomas. To test this hypothesis, various experiments were carried out that show that the first phase of recombination occurs in non-cancerous tissues, which favours the development of CTNNB1 mutations. This mechanism could explain the rapid tumour progression in MLH1-LS-CRC. The results highlight the importance of mitotic recombination in carcinogenesis and provide an insight into the genetic basis of colorectal carcinoma in the context of Lynch syndrome.

Indexed as

Colorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisCarcinogenesisHumansMutL Protein Homolog 1Promoter Regions, GeneticMLH1 protein, humanMutL Protein Homolog 1AdenomaDNA mismatch repairGenetic recombinationHuman CTNNB1 proteinTumor supressor genes

Identifiers

PMID37932477
OpenAlexW4388425018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.