ArticleNature immunology2023
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T
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Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 44 citations in OpenAlex.
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Inflame and restrain - the paradoxical roles of IL-12 and IL-23 in immunity.Nature reviews. Immunology · 2026Review
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- Contextualizing TNature reviews. Immunology · 2026Review
- Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models.EBioMedicine · 2026Article
- Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease.Cellular and molecular life sciences : CMLS · 2026Review
- IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory pain.The Korean journal of pain · 2026Article
- Reframing IL-27: a central regulator of CD8Trends in immunology · 2026Review
- Cytokines Associated with Activation of CD4International journal of molecular sciences · 2026Review
- T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- IL-27, a metabolic regulator secreted by astrocytes in response to GLP-1RA OHP2, modulates microglial reprogramming in Alzheimer's disease by regulating cGAS lactylation.Journal of neuroinflammation · 2026Article
- CXCR3 ameliorates neutrophil-dependent disease severity in SARS-CoV-2 infection by regulating CD4Frontiers in immunology · 2026Article
- Article
- IL27 expression and IL27RA-dependent cellular responses are associated with biochemical recurrence and immune-regulatory features in prostate cancer.Frontiers in immunology · 2026Article
- IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion.eLife · 2025Article
- β-Glucan pretreatment activates lectin pathway to maintain the function of intestinal Th17 cells for infectious enteritis protection.Zoological research · 2025Article
- Intestinal reengineering: Scientific advances in intestinal transplantation.World journal of gastrointestinal surgery · 2025Review
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.Science immunology · 2025Article
- Ligand-receptor interactions induce and mediate regulatory functions of BATF3Science advances · 2025Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 2 countries.
Chia-Hao LinSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Cheng-Jang WuSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7640-5915
Sunglim ChoSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Rasika PatkarSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-6664-5659
William J HuthSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Ling-Li LinSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Mei-Chi ChenSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Elisabeth IsraelssonTranslational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Joanne BettsTranslational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Magdalena NiedzielskaBioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Shefali A PatelDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Han G DuongDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Romana R GernerDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Chia-Yun HsuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5283-1020
Matthew CatleyBioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Rose A MaciewiczBioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Hiutung ChuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7489-0446
Manuela RaffatelluDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6487-4215
John T ChangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Li-Fan LuSchool of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. lifanlu@ucsd.edu.ORCID 0000-0002-9727-0036
University of California San Diego · USAstraZeneca (Sweden) · SELa Jolla Institute for Immunology · US
Funding
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MSingle-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8MRole of microRNAs in regulatory T cell-mediated immunological tolerance and T celR01AI108651 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2014 to 2024
$4.0MC3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1MNutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9MNutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8MThe Microbiome Mediates Protections from Colitis Through Pathways Linked to IBDR00DK110534 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHU, HIUTUNG · 2018 to 2020
$744kAntimicrobial activity of Escherichia coli Nissle 1917 microcin MR21AI154644 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2020 to 2021
$440kFunctional dissection of the Klrg1+ regulatory T cell subset in health and diseasesR21AI163813 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2021 to 2022
$435kSpecialization of regulatory T cell-mediated immune regulation during Toxoplasma infectionR56AI127751 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2017 to 2017
$280kThe Microbiome Mediates Protections from Colitis Through Pathways Linked to IBDK99DK110534 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHU, HIUTUNG · 2016 to 2017
$179kFunction of NLRP3 in regulatory T cell-mediated control of intestinal homeostasisF31DK135162 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATKAR, RASIKA · 2023 to 2024
$82kBLRD VA I01 BX005106NIAID NIH HHS P01 AI132122NIAID NIH HHS R01 AI108651NIAID NIH HHS R01 AI126277NIAID NIH HHS R01 AI145325NIAID NIH HHS R21 AI154644NIAID NIH HHS R21 AI163813NIAID NIH HHS R37 AI126277NIAID NIH HHS R56 AI127751NIDDK NIH HHS F31 DK135162NIDDK NIH HHS K99 DK110534NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R00 DK110534
Abstract
Regulatory T cells (T
Indexed as
Interleukin-27T-Lymphocytes, RegulatoryAnimalsImmune ToleranceImmunity, CellularMiceTh17 CellsT-Lymphocytes, Helper-InducerInterleukin-27
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.