Observational studyDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2024
Acute pancreatitis is associated with gut dysbiosis in children.
Observational study in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls.Journal of pediatric gastroenterology and nutrition · 2026Article
- Clinical and stool microbiome correlates of simple post-ERCP hyperamylasemia in children undergoing therapeutic ERCP for pancreatobiliary obstructive disorders: an exploratory pilot study.Frontiers in pediatrics · 2026Article
- Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes.Journal of pediatric gastroenterology and nutrition · 2025Article
- Acute Pancreatitis in Children: It's Not Just a Simple Attack.Gastroenterology · 2025Review
- Microbiome of the Proximal Small Intestine in Patients with Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2025Article
- Study on the pathogenesis of idiopathic pediatric acute pancreatitis by combining intestinal microbiome and metabolome.Translational pediatrics · 2025Article
- Nutritional parameters following first episode of pediatric acute pancreatitis.Clinical nutrition ESPEN · 2024Observational
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPediatric acute pancreatitis (AP) is associated with significant morbidity. Therefore, improved understanding of children who will develop severe AP is critical. Adult studies have reported AP associated gut dysbiosis, but pediatric studies are lacking.
aimsAssess stool microbial taxonomic and functional profiles of children with first attack of AP compared to those of healthy controls (HC), and between mild and severe AP
methodsChildren under 21 years hospitalized at a tertiary center (n = 30) with first AP attack were recruited including HC (n = 34) from same region. Shotgun metagenomic sequencing was performed on extracted DNA.
resultsDemographics were similar between AP and HC. Alpha diversity (-0.68 ± 0.13, p-value < 0.001), and beta-diversity (R
conclusionsGut dysbiosis occurs in pediatric AP and is associated with AP severity. A multicenter study confirming these findings could pave way for interventional trials manipulating the gut microbiome to mitigate AP severity.
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