Evidence map›Paper›PMID 37932047›Full record

ArticleCold Spring Harbor molecular case studies2023

Synchronous T-lymphoblastic lymphoma and neuroblastoma in a 3-yr-old with novel germline

Pauline Tibout, Joel Livingston, Nisha Kanwar, Kyoko E Yuki, Adam Shlien, Bo Ngan, Meredith S Irwin, Daniel A Morgenstern, Johann Hitzler, Anita Villani and 1 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Pauline TiboutDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.ORCID 0000-0001-5371-0004
Joel LivingstonDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.ORCID 0000-0003-3528-4456
Nisha KanwarDepartment of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Kyoko E YukiDepartment of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Adam ShlienDepartment of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Bo NganDivision of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Meredith S IrwinDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Daniel A MorgensternDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.ORCID 0000-0002-4859-1108
Johann HitzlerDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.ORCID 0000-0003-1158-186X
Anita VillaniDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada.
Sarah Cohen-GogoDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada; sarah.cohen-gogo@sickkids.ca.ORCID 0000-0002-8852-1104
University of Toronto · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-lymphoblastic lymphoma (T-LLy) is the most common lymphoblastic lymphoma in children and often presents with a mediastinal mass. Lymphomatous suprarenal masses are possible but rare. Here, we discuss the case of a previously healthy 3-yr-old male who presented with mediastinal T-LLy with bilateral suprarenal masses. Following initial treatment, surgical biopsy of persisting adrenal masses revealed bilateral neuroblastoma (NBL). A clinical genetics panel for germline cancer predisposition did not identify any pathogenic variants. Combination large panel (864 genes) profiling analysis in the context of a precision oncology study revealed two novel likely pathogenic heterozygous variants:

Indexed as

NeuroblastomaPrecursor Cell Lymphoblastic Leukemia-LymphomaPrecursor T-Cell Lymphoblastic Leukemia-LymphomaChildDNA HelicasesEnhancer of Zeste Homolog 2 ProteinGenetic Predisposition to DiseaseGenetic TestingHumansMaleNuclear ProteinsPrecision MedicineTranscription FactorsDNA HelicasesEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanNuclear ProteinsSMARCA4 protein, humanTranscription FactorsneuroblastomaT-cell lymphoma/leukemia

Identifiers

PMID37932047
PMCPMC10815281
OpenAlexW4388407613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.