Evidence map›Paper›PMID 37931968›Full record

ArticleBMJ open2023

Cohort profile: the longitudinal National Growth and Health Study (NGHS) of black and white girls from Northern California tracking how behavioural and psychosocial risk factors predict cardiovascular risk and biological ageing in midlife and in offspring.

Barbara Laraia, Kristy Brownell, Robin Friebur, Rachel Perera, Erika Brown, Stefanie E Mayer, Ingrid Feng, Sabrina Clermont, Lorrene D Ritchie, Elissa Epel

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005132 (National Growth and Health Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005132 completednot on this map

National Growth and Health Study (NGHS)

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1985 to 2000ConditionsCardiovascular Diseases, Heart Diseases, Obesity, Coronary Disease
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Barbara LaraiaBerkeley Public Health, University of California, Berkeley, California, USA blaraia@berkeley.edu.ORCID 0000-0002-0493-2900
Kristy BrownellDivision of Research, Kaiser Permanente, Oakland, California, USA.
Robin FrieburSchool-Based Health Center, Outside In, Portland, Oregon, USA.
Rachel PereraBerkeley Public Health, University of California, Berkeley, California, USA.
Erika BrownCalifornia Policy Lab, University of California, Berkeley, California, USA.
Stefanie E MayerDepartment of Psychiatry, University of California, San Francisco, California, USA.
Ingrid FengCollege of Osteopathic Medicine, Touro University, Vallejo, California, USA.
Sabrina ClermontIcahn School of Medicine, Mount Sinai, New York City, New York, USA.
Lorrene D RitchieNutrition Policy Institute, University of California Office of the President, Oakland, California, USA.
Elissa EpelDepartment of Psychiatry, University of California, San Francisco, California, USA.
University of California System · USUniversity of California, San Francisco · USExecutive Office of the President · USKaiser Permanente · USMount Sinai Medical Center · USPhiladelphia College of Osteopathic Medicine · USSchool Based Health Alliance · US

Funding

Race, Stress and Dysregulated Eating: Maternal to Child Transmission of ObesityR01HD073568 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI EPEL, ELISSA S., LARAIA, BARBARA A · 2014 to 2018
$2.6M
Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and OffspringR01AG059677 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., LARAIA, BARBARA A · 2019 to 2021
$1.7M
Understanding and Reversing the Effects of Early Life Adversity on Midlife Health: Improving Daily Psychological Stress Responses using an Ecological Momentary InterventionR00AG062778 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAYER, STEFANIE EVA · 2021 to 2023
$747k
Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and OffspringR56AG059677 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., LARAIA, BARBARA A · 2018 to 2018
$690k
Neighborhood Environments and Intergenerational Transmission of Cardiovascular HealthR56HL141878 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI MUJAHID, MAHASIN S · 2018 to 2018
$520k
NHLBI NIH HHS R56 HL141878NIA NIH HHS R00 AG062778NIA NIH HHS R01 AG059677NIA NIH HHS R56 AG059677NICHD NIH HHS R01 HD073568
6 · The paper itself

Abstract

purposeThe National Heart, Lung and Blood Institute Growth and Health Study (NGHS) prospectively collected anthropometric, biospecimens, clinical, health behaviour and psychosocial measures associated with cardiovascular disease from childhood to young adulthood. The aim of the current study was to assess the impact of stress, dysregulated eating and social genomic biomarkers on cardiometabolic risk factors among the original participants now in midlife and their children.

participantsBeginning in 1987-1988, NGHS recruited black and white girls (age 9-10 years) from socioeconomically diverse backgrounds from from three sites: Cincinnati, Ohio; Washington, DC; and Western Contra Costa County, California (N=2379) and followed them for 10 years. The study maintained an 89% retention rate. The current study is 30 years after the start of the original study and focused on the participants of California (n=887) and their children aged 2-17 years. We re-enrolled 624 of 852 eligible participants (73%): 49.2% black and 50.8% white. The mean age was 39.5 years. Among the 645 eligible biological children, 553 were enrolled; 49% black and 51% white, with 51.5% girls and 48.5% boys. The mean age was 9.3 years. FINDINGS TO DATE: Longitudinal analysis of adolescent drive for thinness predicted higher scores for drive for thinness during midlife, which was indirectly associated with greater adult body mass index through adult drive for thinness. Latent trajectory modelling of adolescent growth over 10 years found that women with persistently high weight trajectory had twice the odds of having children who met the definition for obesity compared with the persistently normal group, adjusting for adult weight. FUTURE PLANS: New studies on neighbourhood socioeconomic status, food insecurity and additional biomarkers of chronic stress, microbiome and accelerated ageing (ie, telomere length and epigenetic clock) are underway. We are developing a 10-year follow-up to understand changes in ageing biomarkers of the participants and their children. TRIAL REGISTRATION NUMBER: NCT00005132.

Indexed as

AgingCardiovascular DiseasesHeart Disease Risk FactorsAdolescentAdultBiomarkersBlack or African AmericanBody Mass IndexCaliforniaChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleRisk FactorsBiomarkersEPIDEMIOLOGIC STUDIESHealth EquityPUBLIC HEALTHRisk Factors

Identifiers

PMID37931968
PMCPMC10632866
OpenAlexW4388424568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.